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Current Management of Bacterial Meningitis

  • George H. McCrackenJr.
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 549)

Abstract

The implementation of universal Haemophilus conjugate vaccine immunization in infancy has virtually eliminated H. influenzae type b sepsis and meningitis in the developed worlds. As a result, pneumococci and meningococci are the major pathogens of meningitis in infants and children. Management considerations are based on outcome from treatment of these two organisms.

Keywords

Bacterial Meningitis Invasive Pneumococcal Disease Pneumococcal Meningitis Meningococcal Meningitis Dexamethasone Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Arditi, M., Mason, E.O., Bradley, J.S., Tan, T.Q., Barson, W.J., Schutze, G.E., Wald, E.R., Givner, L.B., Kim, K.S., Yogev, R., and Kaplan, S. L. (1998). Three year multicenter surveillance of pneumococcal meningitis in children. Pediatrics 102, 1087.PubMedCrossRefGoogle Scholar
  2. de Gans, J., Van de Beek, D.; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators. (2002). Dexamethasone in adults with bacterial meningitis. N. Engl. J. Med. 347, 1549.PubMedCrossRefGoogle Scholar
  3. Lebel, M.H., and McCracken, G.H., Jr. (1989). Delayed cerebrospinal fluid sterilization and adverse outcome of bacterial meningitis in infants and children. Pediatrics 83, 161.PubMedGoogle Scholar
  4. Lutsar, I., Friedland, H.S., Jafri, H.S., Wubbel, L., Ahmed, A., Trujillo, M., McCoig, C.C., and McCracken, G.H., Jr. (2003). Factors influencing the anti-inflammatory effect of dexamethasone therapy in experimental pneumococcal meningitis. J. Antimicrob. Chemother. 52, 651.PubMedCrossRefGoogle Scholar
  5. Mclntyre, P.B., Berkey, C.S., King, S.M., Schaad, U.B., Kilpi, T., Kanra, G.Y., and Perez, C.M. (1998). Dexamethasone as adjunctive therapy in bacterial meningitis. J. Amer. Med. Assoc. 278, 925.CrossRefGoogle Scholar
  6. Saravoltz, L.D., Manzor, O., Vander Velde, N., Pawlak, J., and Belian, B. (2003). Broad-range bacterial polymerase chain reaction for early detection of bacterial meningitis. Clin. Infect. Dis. 36, 40.CrossRefGoogle Scholar
  7. Whitney, C.G., Farley, M.M., Hadler, J., Harrison, L.H., Bennett, N.M., Lynfield, R., Reingold, A., Cieslak, P.R., Pilishvili, T., Jackson, D., Facklam, R.R., Jorgensen, J.H., Schuchat, A.; Active Bacterial Core Surveillance of the Emerging Infections Program Network. (2003). Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N. Engl. J. Med. 348, 1737.PubMedCrossRefGoogle Scholar

Copyright information

© Science+Business Media New York 2004

Authors and Affiliations

  • George H. McCrackenJr.

There are no affiliations available

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