RSV and Influenza
Clinical and experimental studies have demonstrated that the pathophysiology of RSV infection is largely due to host responses rather than cytopathic effects of the virus. Therefore the use of anti-inflammatory agents such as steroids appears to be an attractive therapeutic option. This has been studied extensively and a recent meta-analysis concludes that the use of steroids does not reduce the length of stay in hospital by a clinically relevant time (Garrison et al., 2000). A further multicenter RCT study using intravenous Dexamethasone in patients admitted to PICU also did not demonstrate an effect in length of stay in hospital. A subgroup analysis of young infants with bronchiolitis suggested a reduction in duration of ventilation (van Woensel et al., 2003).
KeywordsRespiratory Syncytial Virus Influenza Vaccine Acute Otitis Medium Respiratory Syncytial Virus Infection Swine Influenza
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