New Antibiotics and Bacterial Resistance
Antibiotic resistance for many pediatric pathogens has been increasing steadily over the past decades and has complicated the antibiotic management of both community- and hospital acquired infections. This review will focus on two Gram-positive organisms- Staphylococcus aureus and Streptococcus pneumoniae and selected Gram-negative organisms that are important nosocomial organisms.
KeywordsPneumococcal Conjugate Vaccine Vancomycin Resistant Enterococcus ESBL Produce Invasive Pneumococcal Infection Heptavalent Pneumococcal Conjugate Vaccine
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- Black, S., Shinefield, H., Fireman, B., Lewis, E., Ray, P., Hansen, J.R. et al., and the Northern California Kaiser Permanente Vaccine Study Center Group. (2000). Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr. Infect. Dis. J. 19, 187–195.PubMedCrossRefGoogle Scholar
- Kaplan, S.L. and the United States Pediatric Multicenter Pneumococcal Surveillance Group. (2003b). Decline in invasive Streptococcus pneumoniae infections in eight children’s hospitals, Pediatr. Res. 53:565A. Abstract 3199.Google Scholar
- Martinez A.G., Hammerman, W., Mason, E.O. Jr., and Kaplan, S.L. (2003). Clindamycin treatment of invasive infections caused by community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus in children. Pediatr. Infect. Dis. J. 7, 593–598.Google Scholar
- Patterson, D.L., Ko W.-C., Von Gottberg, V., Casellas, J.M., Mulazimoglu, L., Klugman, K.P. et al. (2001). Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum ß-lactamases: Implications for the clinical microbiology laboratory. J. Clin. Microbiol. 39, 2206–2212.CrossRefGoogle Scholar
- Sattler, C.A., Mason, E.O. Jr., and Kaplan, S.L. (2002). Prospective comparison of risk factors and demographic and clinical characteristics of community-acquired, methicillin-resistant versus methicillin-susceptible Staphylococcus aureus infection in children. Pediatr. Infect. Dis. J. 21, 910–915.PubMedCrossRefGoogle Scholar
- Whitney, C.G., Farley, M.M., Hadler, J., Harrison, L.H., Bennett, N.M., Lynfield, R. et al., and Schuchat, A. for the Active Bacterial Core Surveillance of the Emerging Infections Program Network. (2003). Decline in invasive pneumococcal disease after the introduction of protein-conjugate polysaccharide conjugate vaccine. N. Engl. J. Med. 348, 1737–1746.PubMedCrossRefGoogle Scholar