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Febrile Neutropenia: Past, Present and Future

  • Olaf Neth
  • Nigel Klein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 549)

Abstract

A major advance over the last 40 years has been the improved outcome from common malignancies. This has been due, in part, to the availability and improved usage of effective cytotoxic chemotherapy and supportive care. However in some conditions, such as acute leukemia, the use of empirical antimicrobial therapy has been equally important. This chapter will briefly outline some of the important advances in the management of febrile neutropenia over the last 40 years.

Keywords

Febrile Neutropenia Empirical Antimicrobial Therapy Severe Oral Mucositis Febrile Neutropenic Episode Sequential High Dose Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bodey, G.P., Buckley, M., Sathe, Y.S., and Freireich, E.J. (1966). Quantitative relationships between circulating leukocytes and infection in patients with acute leukaemia. Ann. Intern. Med. 64, 328–340.PubMedGoogle Scholar
  2. Haupt, R., Romanengo, M., Fears, T., Viscoli, C., and Castagnola, E. (2001). Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: A 12-year experience at a single Italian institution. Eur. J. Cancer. 37, 2413–2419.PubMedCrossRefGoogle Scholar
  3. Jack, D., Klein, N., and Turner, M. (2001). Mannose-binding lectin: Targeting the microbial world for complement attack and opsonophagocytosis. Immunol. Rev. 180, 86–99.PubMedCrossRefGoogle Scholar
  4. Neth, O., Jack, D., Johnson, M., Klein, N., and Turner, M. (2002). Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin (MBL) with MBL-associated serine protease following binding to Staphylococcus aureus. J. Immunol. 169, 4430–4436.PubMedGoogle Scholar
  5. Neth, O., Hann, I., Turner, M.W., and Klein, N.J. (2001). Deficiency of mannose-binding lectin and burden of infection in children with malignancy: A prospective study. Lancet 358, 614–618.PubMedCrossRefGoogle Scholar
  6. Peterslund, N.A., Koch, C., Jensenius, J.C., and Thiel, S. (2001). Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet 358, 637–638.PubMedCrossRefGoogle Scholar
  7. Schimpff, S., Satterlee, W., Young, V.M., and Serpick, A. (1971). Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N. Eng. J. Med. 284, 1061–1065.CrossRefGoogle Scholar
  8. Schimpff, S., Gaya, H., Klastersky, J., Tattersall, M.H., and Zinner, S.H. (1978). Three antibiotic regimens in the treatment of infection in febrile granulocytopenic patients with cancer. The EORTC international antimicrobial therapy project group. J. Infect. Dis. 137, 14–29.PubMedCrossRefGoogle Scholar
  9. Viscoli, C. and Castagnola, E. (1995). Factors predisposing cancer patients to infection. Cancer Treat. Res. 79, 1–30.PubMedCrossRefGoogle Scholar
  10. Viscoli, C. and Castagnola, E. (2002). Treatment of febrile neutropenia: What is new? Curr. Opin. Infect. Dis. 15, 377–382.PubMedCrossRefGoogle Scholar

Copyright information

© Science+Business Media New York 2004

Authors and Affiliations

  • Olaf Neth
  • Nigel Klein

There are no affiliations available

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