Pertussis is Back and Now What?

  • Nicole Guiso
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 549)


Vaccination is one of the most successful tools for controlling infectious diseases. Today millions of lives are saved because of vaccination against tetanus, diphtheria, whooping cough, poliomyelitis, meningitis, measles. Although it is generally perceived as the “golden solution,” it has been shown recently that the extensive use of vaccines may lead to undesirable effects (e.g., poliomyelitis epidemics due to vaccine-derived viruses) or the resurgence of a disease (e.g., reemergence of whooping cough after 40 years of vaccination). In the documented cases, epidemiological studies clearly indicate that extensive vaccination can induce modifications of pathogens over time, the emergence of new pathogens due to changes in ecosystems, or change in the transmission of the disease. Therefore, to optimize the benefits of immunization programs and prevent global adverse effects of vaccines (and the subsequent detrimental impact to the general public), the consequences of extensive vaccinations on the pathogen, ecosystem, and/or human host populations remain to be evaluated.


Vaccine Strain Pertussis Toxin Pertussis Vaccine Bordetella Pertussis Whooping Cough 
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© Science+Business Media New York 2004

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  • Nicole Guiso

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