Abstract
Vaccination is one of the most successful tools for controlling infectious diseases. Today millions of lives are saved because of vaccination against tetanus, diphtheria, whooping cough, poliomyelitis, meningitis, measles. Although it is generally perceived as the “golden solution,” it has been shown recently that the extensive use of vaccines may lead to undesirable effects (e.g., poliomyelitis epidemics due to vaccine-derived viruses) or the resurgence of a disease (e.g., reemergence of whooping cough after 40 years of vaccination). In the documented cases, epidemiological studies clearly indicate that extensive vaccination can induce modifications of pathogens over time, the emergence of new pathogens due to changes in ecosystems, or change in the transmission of the disease. Therefore, to optimize the benefits of immunization programs and prevent global adverse effects of vaccines (and the subsequent detrimental impact to the general public), the consequences of extensive vaccinations on the pathogen, ecosystem, and/or human host populations remain to be evaluated.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Centers for Disease Control for Prevention. (2002). Pertussis-United States, 1997-2000. MMWR 51, 73–76.
Baron, S., Njamkepo, E., Grimprel, E., Begue, P., Desenclos, J.C., Drucker, J., and Guiso, N. (1998). Epidemiology of pertussis in French hospitals in 1993 and 1994: Thirty years after a routine use of vaccination. Pediat. Inf. Dis. J. 17, 412–418.
Bordet, J. and Gengou, O. (1906). L’endotoxine coquelucheuse. Ann. Inst. Pasteur 415–419.
Crowcroft, N.S., Andrews, N., Rooney, C., Brisson, M., and Miller, E. (2002). Deaths from pertussis are underestimated in England. Arch. Dis. Child. 86, 336–338.
De Melker, H.E., Schellekens, J.F.P., Neppelenbroek, S.E., Mooi, F.R., Rümke, H.C., and Conyn-van Spaendonck, M.A.E. (2000). Reemergence of pertussis in the highly vaccinated population of the Netherlands: Observations on surveillance data. Emerg. Infect. Dis. 6, 348–357.
Floret, D., Groupe de pathologie infectieuse pédiatrique, and Groupe francophone de réanimation et d’urgence pédiatrique. (2001). Les décès par infection bactérienne communautaire. Enquête dans les services de réanimation pédiatrique français. Arch. Pediatr. 8, 705–711.
Heininger, U., Stehr, K., and Cherry, J.D. (1992). Serious pertussis overlooked in infants. Eur. J. Pediatr. 151, 342–343.
Heininger, U., Stehr, K., Schmidt-Schlapfer, G., Penning, R., Vock, R., Kleemann, W., and Cherry, J.D. (1996). Bordetella pertussis infections and sudden unexpected deaths in children. Eur. J. Pediatr. 155, 551–553.
Juretzko, P., Fabian-Marx, T., Haastert, B., Giani, G., von Kries, R., von Wirsing, K. et al. (2001). Pertussis in Germany: Regional differences in management and vaccination status of hospitalized cases. Epidemiol. Infect. 127, 63–71.
Lindgren, C., Milerad, J., and Lagercrantz, H. (1997). Sudden infant death and prevalence of whooping cough in the Swedish and Norwegian communities. Eur. J. Pediatr. 156, 405–409.
Locht, C., Antoine, R., and Jacob-Dubuisson, F. (2001). Bordetella pertussis, molecular pathogenesis under multiple aspects. Curr. Opin. Microbiol. 4, 82–89.
Mooi, F.R., Van Oirschot, H., Heuvelman, K., Van der Heide, H.G.J., Gaastra, W., and Willems, R.J.L. (1998). Polymorphism in the Bordetella pertussis virulence factors P.69/pertactin and pertussis toxin in the Netherlands: Temporal trends and evidence for vaccine-driven evolution. Infect. Immun. 66, 670–675.
Nicoll, A. and Gardner, A. (1988). Whooping cough and unrecognised postperinatal mortality. Arch. Dis. Child. 63, 41–47.
Njamkepo, E., Rimlinger, F., Thiberge, S., and Guiso, N. (2002). Thirty-five years’ experience with the whole-cell pertussis vaccine in France: Vaccine strains analysis and immunogenicity. Vaccine 20, 1290–1294.
Plotkin, S.A. and Cadoz, M. (1997). The acellular pertussis vaccine trials: An interpretation. Ped. Infect. Dis. J. 16, 508–517; discussion 517-519.
Van Loo, I.H.M., Van der Heide, H.G.J., Nagelkerke, N.J.D., Verhoef, J., and Mooi, F.R. (1999). Temporal trends in the population structure of Bordetella pertussis during 1949-1996 in a highly vaccinated population. J. Infect. Dis. 179, 915–923.
Weber, C., Boursaux-Eude, C., Coralie, G., Caro, V., and Guiso, N. (2001). Polymorphism of Bordetella pertussis isolates circulating the last ten years in France, where a single effective whole-cell vaccine has been used for more than thirty years. J. Clin. Microbiol. 39, 4396–4403.
Wirsing von König, C.H., Halperin, S., Riffelmann, M., and Guiso, N. (2002). Pertussis of adults and infants. Lancet Infect. Dis. 2, 744–750.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Science+Business Media New York
About this paper
Cite this paper
Guiso, N. (2004). Pertussis is Back and Now What?. In: Pollard, A.J., McCracken, G.H., Finn, A. (eds) Hot Topics in Infection and Immunity in Children. Advances in Experimental Medicine and Biology, vol 549. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8993-2_15
Download citation
DOI: https://doi.org/10.1007/978-1-4419-8993-2_15
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4751-4
Online ISBN: 978-1-4419-8993-2
eBook Packages: Springer Book Archive