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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 549))

Abstract

Viral Hepatitis B and C are responsible for a significant burden of disease worldwide. Acute infection is rare in childhood but chronic asymptomatic infection carrying with it a significant risk of chronic liver disease and hepatocellular carcinoma is of significant concern (Bellentani et al., 1999; Chu, 2000).

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References

  • Badizadegan, K., Jonas, M., and Ott, M.J. (1998). Histopathology of the liver in children with chronic hepatitis C viral infection. Hepatology 28, 1416–1423.

    Article  PubMed  CAS  Google Scholar 

  • Bellentani, S., Pozzato, G., and Saccoccio, G. (1999). Clinical course and risk factors of hepatitis C virus related liver disease in the general population: Report from the Dionysos study. Gut 44, 874–880.

    Article  PubMed  CAS  Google Scholar 

  • Bortolotti, F., Jara, P., Barbera, C., Gregorio, G.V., Vegnente, A., Zancan, L. et al. (2000). Long term affect of alpha interferon in children with chronic hepatitis B. Gut 46, 715–718.

    Article  PubMed  CAS  Google Scholar 

  • Boxall, E., Sira, J., El Shukri, N., and Kelly, D.A. (2003). Persistence of hepatitis B antibody in children vaccinated in infancy in a low endemicity country. 11th International Symposium on Viral Hepatitis & Liver Disease, Sydney.

    Google Scholar 

  • Boxall, E., Sira, J., Standish, R.A., Sleight, E., Adeodu, O., Dhillon, A.P. et al. (2004). The natural history of hepatitis B in perinatally infected carriers. Arch. Dis. Child. In press.

    Google Scholar 

  • Bramley, J.C., Wallace, L.A., Ahmed, S., Duff, R., Carman, W.I., Cameron, S.O. et al. (2002). Universal hepatitis B vaccination of UK Adolescents: A feasibility and acceptability study. Commun. Dis. Public Health 5, 318–320.

    PubMed  CAS  Google Scholar 

  • Chang, M.H., Chen, C.J., and Lai, M.S. (1997). Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. N. Eng. J. Med. 336, 1855–1859.

    Article  CAS  Google Scholar 

  • Chang, M.H. (2002). Viral mutants and fulminant hepatitis. A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis. J. Pediat. Gastroenterol. Nutr. 34(4), 426.

    Article  Google Scholar 

  • Choo, Q.L., Kuo, G., Weiner, A.J., Overby, L.R., Bradley, D.W., and Houghton, M. (1989). Isolation of a cDNA clone derived from a blood-borne non-A non-B viral hepatitis genome. Science 22A, 359–362.

    Article  Google Scholar 

  • Chu, C.M. (2000). Natural history of chronic hepatitis B virus infection in adults, emphasis on the occurrence of cirrhosis and hepatocellular carcinoma. J. Gastroenterol. Hepatotol. 15 Supplement, E25-E30.

    Google Scholar 

  • European Paediatric Hepatitis C Virus Network. (2001). Effects of mode of delivery and infant feeding on the risk of mother-to-child transmission of hepatitis C virus. Br. J. Obstet. Gynaecol. 108(4), 371–377.

    Google Scholar 

  • Honda, M., Kaneko, S., and Sakai, A. (1994). Degree of diversity of hepatitis C virus quasispecies and progression of liver disease. Hepatology 20, 1141–1151.

    Article  Google Scholar 

  • Jara, P. and Bortolotti, F. (1999). Interferon-α treatment of chronic hepatitis B in childhood: A consensus advice based on experience in European children. J. Pediatr. Gastroenterol. Nutr. 29, 163–170.

    Article  PubMed  CAS  Google Scholar 

  • Jonas, M., Kelly, D., and Mizerski, J. (2002). Clinical trial of Lamivudine in children with chronic hepatitis B. N. Eng. J. Med. 346, 1706–1713.

    Article  CAS  Google Scholar 

  • Kelly, D.A., Bunn, S., and Apelian, D. (2001). Safety, efficacy and pharmacokinetics of interfeon alfa 2B plus ribavirin in children with chronic hepatitis C. Hepatology 34, 342A.

    Article  Google Scholar 

  • Krogsgaard, K., Marcellin, P., and Trepo, C. (1996). Prednisolone withdrawal therapy enhances the effect of human lymphoblastoid interferon in chronic hepatitis B. INTERPRED Trial Group. J. Hepatol. 25, 803–813.

    Article  PubMed  CAS  Google Scholar 

  • Marcellin, P., Chang, T.T., Lim, S.G., Tong, M.J., Sievert, W., Shiftman, M.L. et al. (2003). Adefovir Dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N. Engl. J. Med. 348(9), 808–816.

    Article  PubMed  CAS  Google Scholar 

  • Perillo, R., Schiff, E., Magill, A., and Murray, A. (1999). In vivo demonstration of sensitivity of YMDD variants to adefovir. Gastroenterology 116A, 1261.

    Google Scholar 

  • Poynard, T., McHutchison, J., and Manns, M. (2002). Impact of pegylated interferon alfa-2b and ribavirin on liver fibrosis in patients with chronic hepatitis C. Gastroenterology 122(5), 1303–1313.

    Article  PubMed  CAS  Google Scholar 

  • Resti, M., Azzari, C., Mannelli, F., and Tuscany Study Group on hepatitis C infection in children. (1998). Mother to child transmission of hepatitis C virus: Prospective study of risk factors and timing of infection in children born to women seronegative for HIV-1. BMJ 317, 437–441.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, E.A., King, S.M., Fearon, M., and McGee, N. (1998). Hepatitis C in children after transfusion: Assessment by look-back studies. Acta Gastroenteml. Belgica. 61(2), 195–197.

    CAS  Google Scholar 

  • Ruiz-Extremera, A., Salmeron, J., and Torres, C. (2000). Follow-up of transmission of hepatitis C to babies of human immunodeficiency virus-negative women: the role of breast-feeding in transmission. Pediatr. Infect. Dis.J. 19(6), 511–516.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, K.B. (2003). The safety, efficacy and pharmacokinetics of peginterferon alfa-2a (40KD) in children with chronic hepatitis C. Digestive Disease Conference, USA.

    Google Scholar 

  • Terrault, N.A. (2002). Treatment of recurrent hepatitis B infection in liver transplant recipients. Liver transpl. 8(10 Supplement 1), S74–S81.

    Article  PubMed  Google Scholar 

  • Thomas, S.L., Newell, M.L., Peckham, C.S., Ades, A.F., and Hall, A.J. (1998). A review of hepatitis C virus (HCV) vertical transmission: Risks of transmission to infants born to mothers with and without HCV viraemia or human immunodeficiency virus infection. International J. Epidemol. 27, 108–117.

    Article  CAS  Google Scholar 

  • Villamil, F.G. (2002). Hepatitis B: progress in the last 15 years, (Review). Liver transpl. 8(10 Supplement 1), S59–S66.

    Article  PubMed  Google Scholar 

  • Vogt, M., Lang, T., and Frosner, G. (1999). Prevalence and clinical outcome of hepatitis C infection in children who underwent cardiac surgery before the implementation of blood donor screening. N. Engl. J. Med. 341, 866–870.

    Article  PubMed  CAS  Google Scholar 

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Kelly, D. (2004). Viral Hepatitis in Children. In: Pollard, A.J., McCracken, G.H., Finn, A. (eds) Hot Topics in Infection and Immunity in Children. Advances in Experimental Medicine and Biology, vol 549. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8993-2_12

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  • DOI: https://doi.org/10.1007/978-1-4419-8993-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4751-4

  • Online ISBN: 978-1-4419-8993-2

  • eBook Packages: Springer Book Archive

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