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Intrinsic Fiber-Optic Sensors for Spatially Resolved Combinatorial Screening

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High-Throughput Analysis

Abstract

Computational methods for the calculation of the structure and properties of molecules have achieved a high degree of accuracy. However, structure-based drug design, while being a powerful approach, often does not afford the reliability needed for targeted synthesis of molecules that show a desired drug action. An alternative approach is the synthesis of large numbers of compounds and the systematic evaluation of these compounds for a desired effect. This approach led to the development of the field of combinatorial chemistry. For the combinatorial approach to be effective, three basic questions must be addressed.

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Author information

Authors and Affiliations

  1. Department of Chemistry, University of Wisconsin-Milwaukee, 3210 N. Cramer Street, Milwaukee, WI, 53211, USA

    Peter Geissinger & Alan W. Schwabacher

Authors
  1. Peter Geissinger
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  2. Alan W. Schwabacher
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Editors and Affiliations

  1. GE Global Research, Schenectady, New York

    Radislav A. Potyrailo

  2. National Institute of Standards and Technology, Gaithersburg, Maryland

    Eric J. Amis

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Geissinger, P., Schwabacher, A.W. (2003). Intrinsic Fiber-Optic Sensors for Spatially Resolved Combinatorial Screening. In: Potyrailo, R.A., Amis, E.J. (eds) High-Throughput Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8989-5_15

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  • DOI: https://doi.org/10.1007/978-1-4419-8989-5_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4749-1

  • Online ISBN: 978-1-4419-8989-5

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