Abstract
Recent developments in combinatorial synthesis and high-throughput screening (HTS) have emphasized parallel strategies for the generation and characterization of large libraries of synthetic molecules. In the era following the sequencing of the human genome [1], proteomics has been developed as a high-throughput approach to the discovery of biological target molecules that are up- or downregulated in diseased cells [2]. The identification of such targets will certainly increase the demand for combinatorial libraries of potential binding ligands that are chemically diverse, well characterized, and appropriate for screening against multiple target molecules.
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Barnes, C.A.S., Clemmer, D.E. (2003). Ion Mobility/Time-of-Flight Analysis of Combinatorial Library Mixtures. In: Potyrailo, R.A., Amis, E.J. (eds) High-Throughput Analysis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8989-5_10
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DOI: https://doi.org/10.1007/978-1-4419-8989-5_10
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