Neuroprotection and Dopamine Agonists

  • Zvezdan Pirtošek
  • Dušan Flisar
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 541)


Parkinson’s disease is a neurodegenerative disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra pars compacta. Accumulating evidence indicates that apoptosis contributes to the cell death in Parkinson’s disease patients’ brain. Excitotoxicity, oxidative stress, and mitochondrial respiratory failure are thought to be the key inducers of the apoptotic cascade. The chapter will review the evidence suggesting that some agents — and dopamine agonists in particular — are neuroprotective and the possible mechanisms whereby these effects might occur.


Substantia Nigra Dopaminergic Neuron Dopamine Agonist Motor Complication Single Photon Emission Computer Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Zvezdan Pirtošek
    • 1
  • Dušan Flisar
    • 2
  1. 1.Centre for Extrapyramidal Disorders, Neurology HospitalUniversity Medical CentreLjubljanaSlovenia
  2. 2.Neurology DepartmentGeneral HospitalMariborSlovenia

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