Experimental Measurement and Analysis of Scattering Force and Gradient Force in Optical Trapping and Manipulation of Micro-particles

  • Arthur Chiou
Part of the Topics in Biomedical Engineering International Book Series book series (ITBE)


Optical trapping and manipulation of micro-particles have received more and more attention in recent years due to their potential biological applications. Aside from serving as a tool, popularly known as optical tweezers, for non-contact and non-invasive controlled manipulation of biological samples, such as cells, bacteria, and organelles, the measurement of forces between biological samples (on the order of pico-newtons) is an important application. For such applications, optical forces on micro-particles have to be measured and calibrated. I begin with a brief introduction to the nature of optical forces on micro-particles, followed by a discussion of optical forces involved in various trapping configurations, and their measurement, along with some preliminary experimental results. The merits and the technical issues associated with these approaches are also discussed briefly.


Gaussian Beam Optical Power Radiation Pressure Viscous Force Switching Frequency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. Ashkin, “Acceleration and trapping of particles by radiation pressure,” Phys. Rev. Lett., vol. 24, pp. 156–159, 1970.CrossRefGoogle Scholar
  2. 2.
    A. Ashkin and J. M. Dziedzic, “Optical levitation by radiation pressure,” Appl. Phys. Lett., vol. 19, pp. 283–285, 1971.CrossRefGoogle Scholar
  3. 3.
    A. Ashkin, J. M. Dziedzic, J. E. Bjorkholm, and S. Chu, “Observation of a single beam gradient force optical trap for dielectric particles,” Opt. Lett., vol. 11, pp. 288–290, 1986.CrossRefGoogle Scholar
  4. 4.
    A. Constable, J. Kim, J. Mervis, F. Zarinetchi, and M. Prentiss, “Demonstration of a fiber-optical light-force trap,” Opt. Lett., vol. 18, pp. 1867–1869, 1993.CrossRefGoogle Scholar
  5. 5.
    A. Chiou, W. Wang, G. J. Sonek, J. Hong, and M. W. Berns, “Interferometric optical tweezers,” Optics Communications, vol. 133, pp. 7–10, 1997.CrossRefGoogle Scholar
  6. 6.
    A. Chiou, “Photorefractive phase-conjugate optics for optical image processing, trapping, and manipulation of microscopic objects,” IEEE Proceeding, Special Issue on Photorefractive Materials, Devices, and Applications, vol. 87, pp. 2072, 1999.Google Scholar
  7. 7.
    K. Saski, “Laser-scarming micromanipulation and spatial patterning of fine particles,” Jpn J. Appl. Phys., vol. 30, pp. L907, 1991.CrossRefGoogle Scholar
  8. 8.
    A. Ashkin, “History of optical trapping and manipulation of small-neutral particles, atoms, and molecules,” IEEE Selected Topics in Quantum Electronics, vol. 6, pp. 841–856, 2000.CrossRefGoogle Scholar
  9. 9.
    A. Pralle, E.-L. Florin, E. H. K. Stelzer, and J. K. Heinrich Horber, “Photonic force microscopy: A new tool providing new methods to study membranes at the molecular level,” Single Mol., vol. 1, pp. 129–133, 2000.CrossRefGoogle Scholar
  10. 10.
    A. L. Stout and W. W. Webb, “Optical Force Microscopy,” in laser Tweezers in Cell Biology, M. P. Sheetz, Ed. San Diego: Academic Press, 1998.Google Scholar
  11. 11.
    W. H. Wright, G. J. Sonek, and M. W. Berns, “Parametric study of the forces on microspheres held by optical tweezers,” Appl. Opt., vol. 33, pp. 1735–1746, 1994.CrossRefGoogle Scholar
  12. 12.
    C. C. Huang, C. F. Wang, D. S. Mehta, and A. E. Chiou, “Optical tweezers as sub-pico-newton force transducers,” Optics Communications, vol. 195, pp. 41–48, 2001.CrossRefGoogle Scholar
  13. 13.
    J. W. Tsai, B. Y. Liao, C. C. Huang, W. L. Hwang, D. W. Wang, A. E. Chiou, and C. H. Lin, “Applications of optical tweezers and an integrated force measurement module for biomedical research,” presented at Optical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications, Taipei, Taiwan, 2000.Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Arthur Chiou
    • 1
  1. 1.Department of Electrical EngineeringNational Dong Hwa UniversityShou-Feng, Hualien

Personalised recommendations