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Do Biochemical Predictors of IVF Outcome Exist?

  • Chapter
Essential IVF

Abstract

Over the past two decades, several molecules (predominantly steroids and proteins) have been explored as potential predictors of IVF outcome. This chapter begins by reviewing the equivocal data for and against “the usual suspects” (ovarian steroids, gonadotrophins, prolactin, etc.) before focusing on the cortisol — Cortisol binding globulin (CBG) - 11 β-hydroxysteroid dehydrogenase (11 βHSD) system. This example has been selected to illustrate how independent studies can reach different clinical conclusions, possibly due to differences in the methods used to obtain and assay samples. In the latter sections of this chapter, ongoing molecular studies, which appear to resolve the controversies surrounding assessments of cortisol metabolism as biochemical predictors of IVF outcome, are summarised. The chapter closes by providing an answer to the essential question: “Do biochemical predictors of IVF outcome exist?”

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  1. Department of Biochemistry & Molecular Biology, Royal Free & University College Medical School, University College London, Rowland Hill Street, London, NW3 2PF, UK

    Anthony E. Michael

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  1. Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA

    Jonathan Van Blerkom

  2. Colorado Reproductive Endocrinology, Rose Medical Center, Denver, Colorado, USA

    Jonathan Van Blerkom

  3. Cardiff Assisted Reproduction Unit, University Hospital of Wales, Heath Park Cardiff, Wales, UK

    Linda Gregory

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Michael, A.E. (2004). Do Biochemical Predictors of IVF Outcome Exist?. In: Van Blerkom, J., Gregory, L. (eds) Essential IVF. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8955-0_4

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