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Bladder Disease, Part A pp 217–237Cite as

The Role of Lipids and Lipid Metabolites in Urinary Bladder Dysfunction Induced by Partial Outlet Obstruction

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Abstract

Benign prostate hyperplasia (BPH) frequently progresses to cause partial outlet obstruction of the urinary bladder, resulting in a range of symptoms including urine retention, poor flow, nocturia, and detrusor instability. Over 80% of males 50 to 60 years of age and older have various degrees of bladder outlet obstruction secondary to BPH that results in urinary dysfunction.23,34 The urinary dysfunction in men with BPH is related to functional,47 structural,21,59 and biochemical46 changes that occur in both the smooth muscle and urothelial components of the urinary bladder during urethral obstruction by the enlarged prostate. However, the specific pathophysiology that leads to BPH symptoms remains unknown.86 The ability to develop rational therapeutic interventions for the treatment of bladder dysfunction associated with BPH requires an understanding of the pathological changes that occur in the underlying cellular mechanisms responsible for maintaining normal bladder function

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  1. Department of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY, USA

    Martha A. Hass & Robert M. Levin

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  1. Children’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Anthony Atala

  2. Ridgefield, Connecticut, USA

    Debra Slade

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Hass, M.A., Levin, R.M. (2003). The Role of Lipids and Lipid Metabolites in Urinary Bladder Dysfunction Induced by Partial Outlet Obstruction. In: Atala, A., Slade, D. (eds) Bladder Disease, Part A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8889-8_16

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