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Radiochemotherapy in Locally Invasive Non-Metastatic Carcinoma of the Bladder

  • J. L. Brod
  • R. Kühn
  • W. Schafhauser
  • K. M. Schrott

Summary

We therefore believe that our therapeutic concept is a true alternative to primary cystectomy, with comparable survival rates. We observed a high rate of functional organ preservation in long-term survivors (79% with complete remission (CR) after 5 years). Radiation bladders were rare at doses not exceeding 60 Gy. Age and co-morbidity were not exclusion criteria. Presence of a competent and cooperative radiotherapy department is a precondition to preventing akinetic radiation bladders. Continuous life-long follow-up is necessary.2 Cystectomy, together with modern urinary diversions, is still necessary; it is performed in non-responders and in patients with muscle-invasive recurrences.

Keywords

Bladder Cancer Radical Cystectomy Positive Resection Margin Comparable Survival Rate Radiation Cystitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Blandy JP, England HR, Evans SJW et al: T3 bladder cancer: The case for salvage cystectomy. Br J Urol, 52:506, 1980.PubMedCrossRefGoogle Scholar
  2. 2.
    Block T, Kriegmair M, Busch M, Weiss M: Harnblasenkarzinom. In Schmeller N, ed. Empfehlungen zur Diagnostik und Therapie und Nachsorge: Urogenitale Tumoren. Tumorzentrum München 1997.Google Scholar
  3. 3.
    Clavel J, Cordier S, Boccon - Gibod Lhemon D: Tobacco and bladder cancer in males. Increased risk for inhalers and smokers of black tobacco. Int J Cancer 44:605, 1984.CrossRefGoogle Scholar
  4. 4.
    Dunst J, Sauer R, Schrott KM, Kühn R, Wittekind C, Altendorf-Hoffmann A: Organ Sparing Treatment of Advanced bladder cancer: A 10 year experience. Int J of Radiation Oncol Biol Phys, 30(2):261, 1994.CrossRefGoogle Scholar
  5. 5.
    Göckcebay E, Riedmiller H, Stöckle M, Hohenfellner R: Urethrale Tumorrezidive nach Radikaler Zystoprostatektomie — Eine Indikation zur primären Zystoprostato-Urethrektomie? Urologe A, 28(4):199, 1989.Google Scholar
  6. 6.
    Hartenstein R: Harnblasenkarzinom. In: Huhn D, Herrmann R, eds. Medikamentöse Therapie maligner Erkrankungen. Fischer Verlag Stuttgart pp 364–373, 1995.Google Scholar
  7. 7.
    International union against cancer. In: Sobin LH, Wittekind C, eds. TNM classification of malignant tumours, 5th ed. New York: Wiley Liss, 1997.Google Scholar
  8. 8.
    Jensen OM, Estere J, Moller J, Renard H: Cancer in the European community and its member states. Eur J Cancer, 26:1167, 1990.PubMedCrossRefGoogle Scholar
  9. 9.
    Mostofi FK, Sobin LH, Torloni H: Histological typing of urinary bladder tumours. International classification of tumours, No 10. WHO, Geneva 1973.Google Scholar
  10. 10.
    Norpoth K, Woitowitz HJ: Beruflich verursachte Tumoren, Detuscher Ärzteverlag Köln ISBN 3-7691-0304-1, 1994.Google Scholar
  11. 11.
    Kaufman DS, Shiplet NU, Henry NM: Invasive bladder carcinoma: Rationale for radiotherapy with potential bladder sparing. In: Fitzpatrick JM, ed. The bladder. New York: Churchill Livingstone, p. 351–539, 1995.Google Scholar
  12. 12.
    Ritchie JP, Shipley WU, Yagoda A: Cancer of the bladder. In: De Vita VT, Hellmann S, Rosenberg SA, eds. Cancer principles and practice of oncology. Philadelphia: J B Lipincott, p. 1008–1020, 1989.Google Scholar
  13. 13.
    Voges GE, Tauschke E, Stöckle M, Alken P, Hohenfellner R: Computerized tomography — an unreliable method for accurate staging of bladder tumours in patients who are candidates for radical cystectomy. J Urol, 142:972, 1989.PubMedGoogle Scholar
  14. 14.
    Yagoda A: Chemotherapy of urothelial tract tumors. Cancer, 60(Suppl):574, 1987.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • J. L. Brod
    • 1
  • R. Kühn
    • 1
  • W. Schafhauser
    • 1
  • K. M. Schrott
    • 1
  1. 1.University Department of UrologyFriedrich Alexander University of Erlangen-NurembergGermany

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