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Antibodies pp 189-197 | Cite as

Macrophages for Immunotherapy

Activated Macrophages plus anti-tumour antibodies in adoptive immunotherapy
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Abstract

Macrophage efficiently kill and phagocyte tumour cells in vitro. To harness the potential therapeutic value of these cells, we have developed a single use Cell Processor able to generate large number of clinical grade Monocyte-derived Activated Killer cells (MAK®). These macrophages were armed with a bispecific antibody (MDX-H210, Medarex Inc., Keler, 1997), recognizing CD64/FcγRl (on the MAK cell) and the oncoprotein HER-2/neu on tumour cell and present several anti-tumoural effector functions.

Keywords

Ovarian Cancer Patient Bispecific Antibody Epithelial Ovarian Cancer Patient Conjugate Formation Cell Processor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  1. 1.IDM (Immuno Designed Molecule)Paris Cedex 11France

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