Over the last 15 years, we have produced monoclonal antibodies directed specifically against tumor cells, especially carcinoma cells. 150.000 supernatants of growing hybridoma cells coming from 150 different somatic fusions of spleen cells from mice immunized with different immunogens and protocols, were screened for specific reactivity on tumor cells. Only 45 monoclonal antibodies were selected for basic researches and clinical applications.
KeywordsSomatic Fusion Bispecific Monoclonal Antibody Antitumor Antibody Bivalent Antibody Sacchini Versus
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