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Role of Mn-SOD Induction in the Second Window Phenomenon of Preconditioning of Ischemic Hearts

  • Tsunehiko Kuzuya
  • Masashi Nishida
  • Shiro Hoshida
  • Nobushige Yamashita
  • Michihiko Tada
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 194)

Abstract

Recently, growing numbers of evidence suggest that the myocardium undergoes adaptation after sub-lethal cellular stresses including ischemia, heat stress and exposure to cytokines.1-4 The second window, or late phase, of ischemic preconditioning, is one of the adaptation phenomena after non-lethal ischemia, which specifically observed 24 hr after ischemic preconditioning. The mechanism of the acquisition of tolerance to ischemia-reperfusion in the myocardium is still the matter of discussion. However, de novo synthesis of rescue proteins, such as heat shock proteins and antioxidants, are strongly implicated in molecular mechanism of the cellular protection. In this review, we will focus on the aspect of oxygen radical metabolism in the heart at ischemia-reperfusion and outline our recent findings on the role of manganese superoxide dismutase, an intrinsic oxygen radical scavenger localized in mitochondria, in the protection of myocardium from ischemia-reperfusion.

Keywords

Leave Anterior Descend Cardiac Myocytes Hypoxic Precondition Prolonged Hypoxia Creatine Kinase Release 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Tsunehiko Kuzuya
  • Masashi Nishida
  • Shiro Hoshida
  • Nobushige Yamashita
  • Michihiko Tada

There are no affiliations available

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