The Late Phase of Preconditioning Against Myocardial Stunning

  • Roberto Bolli
  • Yumin Qiu
  • Xian-Liang Tang
  • Seong-Wook Park
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 194)

Abstract

It has recently become apparent that there are two phases of ischemic preconditioning against myocardial stunning: an early phase, which begins within minutes, and a late phase, which begins after >6 h.1 These two phases have different pathophysiology and probably different mechanisms. Although the early phase is somewhat controversial, most of the discrepancies can be explained by differences in the duration of the ischemic insult, as detailed in ref. 1; that is, the available evidence indicates that an episode of ischemia protects against the stunning induced by a second ischemic episode when the second episode lasts ≤, 5 min but not when it lasts ≥ 10 min. When early preconditioning does take place, the protection is limited to only a few ischemic episodes (probably less than five).1 In addition to this early phase of protection, brief ischemia induces a late phase of preconditioning against stunning. This late phase lasts much longer and therefore is likely to be more important from a clinical standpoint.1 The purpose of this essay is to succinctly review the existing knowledge regarding the pathophysiology and pathogenesis of late preconditioning against myocardial stunning.

Keywords

Ischemia Attenuation Superoxide Glycine Adenosine 

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References

  1. 1.
    Bolli R. The early and late phases of preconditioning against myocardial stunning and the essential role of oxyradicals in the late phase: an overview. Basic Res Cardiol 1996;91:57–63.PubMedCrossRefGoogle Scholar
  2. 2.
    Sun J-Z, Tang X-L, Knowlton AA et al. Late preconditioning against myocardial stunning: An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 hours after brief ischemia in conscious pigs. J Clin Invest 1995; 95:388–403.PubMedCrossRefGoogle Scholar
  3. 3.
    Tang X-L, Qiu Y, Park S-W, et al. Time course of late preconditioning against myocardial stunning in conscious pigs. Circ Res 1996; 79:424–434.PubMedCrossRefGoogle Scholar
  4. 4.
    Qiu Y, Maldonado C, Tang X-L et al. Late preconditioning against myocardial stunning in conscious rabbits. Circulation 1995; (Suppl I):I–389, (Abstr.).Google Scholar
  5. 5.
    Sun J-Z, Tang X-L, Park S-W et a!. Evidence for an essential role of reactive oxygen species in the genesis of late preconditioning against myocardial stunning in conscious pigs. J Clin Invest 1996;97:562–576.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Roberto Bolli
  • Yumin Qiu
  • Xian-Liang Tang
  • Seong-Wook Park

There are no affiliations available

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