Anti-ischemic Effects of the ATP-sensitive Potassium Channel Opener During Coronary Angioplasty
Since Gross and co-workers1 found that glibenclamide completely blocked the infarct size-reducing effect afforded by ischemic preconditioning in canine hearts, it has been widely known that the ATP-sensitive potassium (KATP) channel activation plays an important role in myocardial protection against ischemia-reperfusion injury in several species, and a number of laboratories have demonstrated that KATP channel openers such as nicorandil,2 bimakalim,3 and aprikalim1 mimic the cardioprotective effect of ischemic preconditioning.
KeywordsCatheter Ischemia Attenuation Adenosine Nifedipine
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- 8.Mizumura T, Nithipatikom K, Gross GJ. Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs. Cardiovasc Res. In pressGoogle Scholar