Anti-ischemic Effects of the ATP-sensitive Potassium Channel Opener During Coronary Angioplasty

  • Satoshi Saito
  • Tsuneo Mizumura
  • Tadateru Takayama
  • Junko Honye
  • Masahito Moriuchi
  • Yukio Ozawa
  • Katsuo Kanmatsuse
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 194)

Abstract

Since Gross and co-workers1 found that glibenclamide completely blocked the infarct size-reducing effect afforded by ischemic preconditioning in canine hearts, it has been widely known that the ATP-sensitive potassium (KATP) channel activation plays an important role in myocardial protection against ischemia-reperfusion injury in several species, and a number of laboratories have demonstrated that KATP channel openers such as nicorandil,2 bimakalim,3 and aprikalim1 mimic the cardioprotective effect of ischemic preconditioning.

Keywords

Catheter Ischemia Attenuation Adenosine Nifedipine 

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References

  1. 1.
    Gross GJ, Auchampach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res. 1992; 70: 223–233.PubMedCrossRefGoogle Scholar
  2. 2.
    Lamping KA, Christensen CW, Pelc LR et al. Effects of nicorandil and nifedipine on protection of ischemic myocardium. J Cardiovasc Pharmacol. 1984; 6: 536–542.PubMedCrossRefGoogle Scholar
  3. 3.
    Yao Z, Gross GJ. Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs. Circulation. 1994; 89:1769–1775.PubMedCrossRefGoogle Scholar
  4. 4.
    Deutsch E, Berger M, Kussmaul WG et al. Adaptation to ischemia during percutaneous transluminal coronary angioplasty: Clinical, hemodynamic, and metabolic features. Circulation. 1990; 82: 2044–2051.PubMedCrossRefGoogle Scholar
  5. 5.
    Tomai F, Crea F, Gaspardone A et al. Ischemic preconditioning during coronary angioplasty is prevented by glibenclamide, a selective ATP-sensitive K+ channel blocker. Circulation. 1994; 90: 700–705.PubMedCrossRefGoogle Scholar
  6. 6.
    Saito S, Mizumura T, Takayama T et al. Antiischemic effects of nicorandil during coronary angioplasty in humans. Cardiovasc Drugs Ther. 1995;9:257–263.PubMedCrossRefGoogle Scholar
  7. 7.
    Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74: 1124–1136.PubMedCrossRefGoogle Scholar
  8. 8.
    Mizumura T, Nithipatikom K, Gross GJ. Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs. Cardiovasc Res. In pressGoogle Scholar
  9. 9.
    Mizumura T, Nithipatikom K, Gross GJ. Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog. Cardiovasc Res. 1995;29: 482–489.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Satoshi Saito
  • Tsuneo Mizumura
  • Tadateru Takayama
  • Junko Honye
  • Masahito Moriuchi
  • Yukio Ozawa
  • Katsuo Kanmatsuse

There are no affiliations available

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