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Proteolytic Cleavage of Poly(ADP-Ribose) Polymerase in Human Leukemia Cells Treated with Etoposide and other Cytotoxic Agents

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ADP-Ribosylation Reactions

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Abstract

Poly(ADP-ribose) polymerase (pADPRp, EC 2.4.2.30) is a nuclear enzyme that catalyzes the transfer of ADP-ribose units from NAD to various protein acceptors (reviewed in 1, 2). The activity of pADPRp in vitro is markedly stimulated by nicked DNA (3, 4), Likewise, pADPRp activity increases when nicks and single-stranded DNA regions are generated in vivo during the repair of DNA damage caused by alkylating agents (5).

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Author information

Authors and Affiliations

  1. The Johns Hopkins Oncology Center, Baltimore, MD, 21205, USA

    Scott H. Kaufmann

  2. Laboratory of Poly(ADP-ribose) Metabolism, Molecular Endocrinology Dept., Laval University Medical Center, Ste-Foy, Quebec, G1V 4G2, Canada

    Serge Desnoyers & Guy G. Poirier

  3. Department of Biology, University of Sherbrooke, Sherbrooke, Quebec, J1K 2R1, Canada

    Brian Talbot

Authors
  1. Scott H. Kaufmann
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  2. Serge Desnoyers
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  3. Brian Talbot
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  4. Guy G. Poirier
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Editor information

Editors and Affiliations

  1. Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Quebec, G1V 4G2, Canada

    Guy G. Poirier

  2. Biochemistry Department Pavillon Vachon, Universite Laval, Quebec, G1K 7P4, Canada

    Pierre Moreau

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© 1992 Springer Science+Business Media New York

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Kaufmann, S.H., Desnoyers, S., Talbot, B., Poirier, G.G. (1992). Proteolytic Cleavage of Poly(ADP-Ribose) Polymerase in Human Leukemia Cells Treated with Etoposide and other Cytotoxic Agents. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_46

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  • DOI: https://doi.org/10.1007/978-1-4419-8718-1_46

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6456-9

  • Online ISBN: 978-1-4419-8718-1

  • eBook Packages: Springer Book Archive

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