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ADP-Ribosylation Reactions pp 242–246Cite as

In Vivo Evidence in Humans of an Association Between ADP-Ribosylation Levels in Mononuclear Leukocytes and Immune Function

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Abstract

Historically, mononuclear leukocytes (MNL) have been the principal cell source used for estimation of cancer risk in humans. Despite repeated demonstrations of effects from genotoxic exposures in vivo on MNL, evidenced by elevated levels of DNA damage (e.g., cytogenetic abnormalities, and DNA adducts, strand breaks and repair inhibition), it only recently has been appreciated what DNA damage does to the function of MNL (1,2). This is an important switch in emphasis, from one where MNL were viewed as a surrogate cell system, reflecting genetic factors or carcinogenic exposures present in epithelial cells (i.e., target cells for cancer), to one where MNL are viewed more as target cells for cancer development because of their role in the immune function (3).

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Authors
  1. Ronald W. Pero
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  2. Hakan Olsson
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  3. Leif Salford
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  4. Walter Troll
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Editor information

Editors and Affiliations

  1. Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Quebec, G1V 4G2, Canada

    Guy G. Poirier

  2. Biochemistry Department Pavillon Vachon, Universite Laval, Quebec, G1K 7P4, Canada

    Pierre Moreau

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© 1992 Springer Science+Business Media New York

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Pero, R.W., Olsson, H., Salford, L., Troll, W. (1992). In Vivo Evidence in Humans of an Association Between ADP-Ribosylation Levels in Mononuclear Leukocytes and Immune Function. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_42

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  • DOI: https://doi.org/10.1007/978-1-4419-8718-1_42

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6456-9

  • Online ISBN: 978-1-4419-8718-1

  • eBook Packages: Springer Book Archive

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