Abstract
Our laboratory has focused in part on utilizing molecular aspects of the PADPRP gene sequences located on chromosome lq as well as on 13 to help clarify the biological role of these genes. With respect to chromosome lq stably transfected cell lines have been established in HeLa cells which express a reverse complementary transcription product in vivo to the exons coded for on this chromosome locus. Also, in the case of the PADPRP-like gene on chromosome 13q, we have fine mapped this sequence and have observed a linkage of deletion of this region with predisposition to various forms of cancer, especially in the African-American population.
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References
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© 1992 Springer Science+Business Media New York
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Smulson, M.E. (1992). Strategies for Studying the Functions of PADPRP Genes on Human Chromosomes 1 and 13. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_4
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DOI: https://doi.org/10.1007/978-1-4419-8718-1_4
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