Poly(ADP-ribose) Synthesis in Lymphocytes of Systemic Lupus Erythematosus Patients

  • Hai-Ying Chen
  • Raymond M. Pertusi
  • Bernard Rubin
  • Elaine L. Jacobson
Conference paper

Abstract

Several studies have implicated altered poly(ADP-ribose) metabolism in the disease systemic lupus erythematosus (SLE). For example, circulating antibodies to poly(ADP-ribose) (1, 2) and poly(ADP-ribose) polymerase (3) have been reported in patients with SLE. In addition, Sibley et al. (4) have reported a 70 percent decrease in the accumulation of ADP-ribose polymers of peripheral blood lymphocytes of patients with SLE. We have confirmed this finding and report here studies on the mechanism of this defective metabolism.

Keywords

Arthritis HPLC Adenosine Diphosphate Lyase 

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Hai-Ying Chen
  • Raymond M. Pertusi
  • Bernard Rubin
  • Elaine L. Jacobson

There are no affiliations available

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