Poly(ADP-ribose) Synthesis in Lymphocytes of Systemic Lupus Erythematosus Patients
Several studies have implicated altered poly(ADP-ribose) metabolism in the disease systemic lupus erythematosus (SLE). For example, circulating antibodies to poly(ADP-ribose) (1, 2) and poly(ADP-ribose) polymerase (3) have been reported in patients with SLE. In addition, Sibley et al. (4) have reported a 70 percent decrease in the accumulation of ADP-ribose polymers of peripheral blood lymphocytes of patients with SLE. We have confirmed this finding and report here studies on the mechanism of this defective metabolism.
KeywordsArthritis HPLC Adenosine Diphosphate Lyase
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