Poly(ADP-ribose) Synthesis in Lymphocytes of Systemic Lupus Erythematosus Patients

  • Hai-Ying Chen
  • Raymond M. Pertusi
  • Bernard Rubin
  • Elaine L. Jacobson


Several studies have implicated altered poly(ADP-ribose) metabolism in the disease systemic lupus erythematosus (SLE). For example, circulating antibodies to poly(ADP-ribose) (1, 2) and poly(ADP-ribose) polymerase (3) have been reported in patients with SLE. In addition, Sibley et al. (4) have reported a 70 percent decrease in the accumulation of ADP-ribose polymers of peripheral blood lymphocytes of patients with SLE. We have confirmed this finding and report here studies on the mechanism of this defective metabolism.


Systemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Polymerase Activity Disease Systemic Lupus Erythematosus Systemic Lupus Erythematosus Group 
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  1. 1.
    Clayton, A. L, Berstein, R.M., Tavassoli, M., Shall, S., Bunn, C., Hughs, G. R. V., Chantier, S. M. Measurement of Antiboty to Poly(adenosine diphosphate-ribose): Its Diagnostic Value in Systemic Lupus Erythematosus. (1984) Clin. Exp. Immunol. 56, 263–271.PubMedGoogle Scholar
  2. 2.
    Kanai, Y., Kawaminami, Y., Miwa, M., Matsushima, T., Sugimura, T., Moroi, Y., and Yokohari, R. Naturally Occurring Antibodies to Poly(ADP-ribose) in Patients with Systemic Lupus Erythematosus. (1977) Nature 265, 175.PubMedCrossRefGoogle Scholar
  3. 3.
    Muller, S., personal communication.Google Scholar
  4. 4.
    Sibley, J. T., Haug, B. L., and Lee, J. S. Altered Metabolism of Poly(ADP-ribose) in the Peripheral Blood Lymphocytes of Patients with Systemic Lupur Erythematosus. (1989) Arthritis and Rheumatism 32, 1045–1049.PubMedCrossRefGoogle Scholar
  5. 5.
    Berger, N. A., Sikorski, G. W., Petzold, S. J., and Kurohara, K. K. Association of Poly(adenosine diphosphate ribose) Synthesis with DNA Damage and Repair in Normal Human Lymphocytes. (1979) J. Clin. Invest. 63, 1164–1171.PubMedCrossRefGoogle Scholar
  6. 6.
    Jacobson, M. K., Aboul-Ela, N., Cervantes-Laurean, D., Loflin, P. T., and Jacobson, E. L. ADP-Ribose Levels in Animal Cells. (1990) In ADP-ribosylating Toxins and G-Proteins: Insights into Signal Transduction, J. Moss and M. Vaughan, Eds., American Society for Microbiology, Washington, D.C., pp. 479–492.Google Scholar
  7. 7.
    Rankin, P. W., Jacobson, E. L., Benjamin, R. C., Moss, J. and Jacobson, M. K. Quantitative Studies of Inhibitors of ADP-Ribosylation In Vitro and In Vivo. (1989) Journal of Biological Chemistry, 264, 4312–4317.PubMedGoogle Scholar
  8. 8.
    Harris, G., Asbery, L., Lawley, P. D., Denman, A. M., Hylton, W. Defective Repair of O6 Methylguanine in Autoimmune Diseases. (1982) Lancet II, 952–956.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Hai-Ying Chen
  • Raymond M. Pertusi
  • Bernard Rubin
  • Elaine L. Jacobson

There are no affiliations available

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