Poly(ADP-ribose) Synthesis in Lymphocytes of Systemic Lupus Erythematosus Patients
Several studies have implicated altered poly(ADP-ribose) metabolism in the disease systemic lupus erythematosus (SLE). For example, circulating antibodies to poly(ADP-ribose) (1, 2) and poly(ADP-ribose) polymerase (3) have been reported in patients with SLE. In addition, Sibley et al. (4) have reported a 70 percent decrease in the accumulation of ADP-ribose polymers of peripheral blood lymphocytes of patients with SLE. We have confirmed this finding and report here studies on the mechanism of this defective metabolism.
KeywordsSystemic Lupus Erythematosus Systemic Lupus Erythematosus Patient Polymerase Activity Disease Systemic Lupus Erythematosus Systemic Lupus Erythematosus Group
Unable to display preview. Download preview PDF.
- 3.Muller, S., personal communication.Google Scholar
- 6.Jacobson, M. K., Aboul-Ela, N., Cervantes-Laurean, D., Loflin, P. T., and Jacobson, E. L. ADP-Ribose Levels in Animal Cells. (1990) In ADP-ribosylating Toxins and G-Proteins: Insights into Signal Transduction, J. Moss and M. Vaughan, Eds., American Society for Microbiology, Washington, D.C., pp. 479–492.Google Scholar