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ADP-Ribosylation Reactions pp 133–136Cite as

Variation in Poly(ADP-ribose) Polymerase Activity and 2’, 5’-Oligoadenylates Core Concentration in Estrogen-Stimulated Uterus and Liver of Immature and Adult Rats

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Abstract

Since the finding that some 2’, 5’-oligoadenylates (ppp(A2’p)nA, 1≤n≤6, referred to as ppp2’,5’An) and their core (2’,5’An) inhibit poly(ADPribose) polymerase (pADPRP) activity in vitro (1), it has been postulated that these substances could act as endogenous inhibitors of pADPRP, modulating the activity of the enzyme in response to different stimuli (1-3). Several results suggest that pADPRP activity and the concentration of ppp2’,5’An and 2’,5’An can be regulated by steroid hormones (4-10). Estrogen induced an enhancement of pADPRP activity (3-5), while at the same time a decrease of the concentration of ppp2’,5’An and/or 2’,5’An occurred (3, 6, 8). On the other hand, glucocorticoids were found to induce the opposite effect in various cells and organs (7, 9, 10).

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References

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Authors
  1. H. Suzuki
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  2. D. Tornese Buonamassa
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  3. L. Cicatielloand
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  4. A. Weisz
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Editor information

Editors and Affiliations

  1. Centre de Recherches en Endocrinologie Moleculaire, Le Centre Hospitalier de l’Universite Laval, Quebec, G1V 4G2, Canada

    Guy G. Poirier

  2. Biochemistry Department Pavillon Vachon, Universite Laval, Quebec, G1K 7P4, Canada

    Pierre Moreau

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© 1992 Springer Science+Business Media New York

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Suzuki, H., Buonamassa, D.T., Cicatielloand, L., Weisz, A. (1992). Variation in Poly(ADP-ribose) Polymerase Activity and 2’, 5’-Oligoadenylates Core Concentration in Estrogen-Stimulated Uterus and Liver of Immature and Adult Rats. In: Poirier, G.G., Moreau, P. (eds) ADP-Ribosylation Reactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8718-1_22

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  • DOI: https://doi.org/10.1007/978-1-4419-8718-1_22

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6456-9

  • Online ISBN: 978-1-4419-8718-1

  • eBook Packages: Springer Book Archive

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