Structure and function of the human poly(ADP-ribose) polymerase

  • Miguel Molinete
  • Valérie Schreiber
  • Frédéric Simonin
  • Gérard Gradwohl
  • Josiane Ménissier-de Murcia
  • Gilbert de Murcia


A number of roles have been ascribed to poly(ADP-ribose) polymerase, (PARP; EC., including involvement in DNA repair, cell proliferation, differentiation and transformation (1-4). One of our major goals is to understand the molecular basis of the complex mechanism leading to the PARP activation in response to DNA strand breaks. Cloning of the gene has allowed the development of molecular biological tools to elucidate the structure and the function(s) of this highly conserved enzyme. This paper describes the recent results obtained in our laboratory using these new approaches.


Catalytic Domain Nuclear Location Signal Nuclear Location Signal Sequence Human Poly Nuclear Location Signal Motif 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Miguel Molinete
    • 1
  • Valérie Schreiber
    • 1
  • Frédéric Simonin
    • 1
  • Gérard Gradwohl
    • 1
  • Josiane Ménissier-de Murcia
    • 1
  • Gilbert de Murcia
    • 1
  1. 1.Institut de Biologie Moléculaire et Cellulaire du CNRSStrasbourg cedexFrance

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