Hair Cell Loss and Synaptic Loss in Inferior Colliculus of C57BL/6 MICE
The C57BL/6 mouse is an extremely popular animal model of presbycusis because of its relatively short life span and genetic pattern of high-frequency sensorineural hearing loss (SNHL) (Henry and Chole, 1980; Willott, 1984; Erway et al., 1993) that resembles the age-related hearing loss seen in humans (Nadol, 1993). Presbycusis and SNHL have traditionally been thought of as peripheral disorders that mainly result in the loss of sensitivity and frequency selectivity (Schmiedt and Schulte, 1992). However, recent studies suggest that peripheral pathologies can lead to functional and anatomical changes in the central nervous system (Hall, 1974, 1976; Wightman, 1982; Morest and Bohne, 1983; Willott, 1984; Salvi and Arehole, 1985; Arehole et al., 1987a; Robertson and Irvine, 1989; Salvi et al., 1990) that may contribute to some of the hearing deficits associated with SNHL and presbycusis.
KeywordsHearing Loss Hair Cell Sensorineural Hearing Loss Inferior Colliculus Auditory Brainstem Response
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