Advertisement

Plasticity of Inferior Colliculus and Auditory Cortex Following Unilateral Deafening in Adult Ferrets

  • David R. Moore
  • Susan J. France
  • David McAlpine
  • Jennifer E. Mossop
  • Huib Versnel

Abstract

Our studies of the effects of unilateral deafening on the brain have been motivated, in part, by a desire to understand some of the short- and long-term mechanisms underlying clinical hearing loss, and partly by a desire to address basic questions in neurobiology, such as how afferent activity, and its withdrawal and modulation, affect the development and maintenance of neuron form, function, and connectivity. To date, much of our research, and that of others, has focused on the effect of deafening on the immature auditory system. This work has shown (Fig. 1), among other things (see chapter by Rubel, this volume), that surgical removal of one cochlea in neonatal mammals leads to: (a) a loss and shrinkage of neurons in the cochlear nucleus (CN; Hashisaki and Rubel, 1989; Moore, 1990; Moore and O’Leary, 1997; Tierney et al., 1997) and superior olivary complex (SOC; Moore, 1992; Pasic et al., 1994; Moore and Pallas, 1997), (b) the formation of new connections between the CN on the intact side and various target structures in the brain- stem (Kitzes et al., 1995; Russell and Moore, 1995) and midbrain (Nordeen et al., 1983; Moore and Kitzes, 1985; Moore, 1994), and (c) an increase in the responsiveness of inferior colliculus (IC; Kitzes, 1984; Kitzes and Semple, 1985; Moore et al., 1993) and primary auditory cortex (AI; Reale et al., 1987) neurons to acoustic stimulation of the ipsilateral, intact ear. In this paper, we focus on the latter, physiological effects of cochlear ablation. In particular, we compare some recent data showing the short- and long- term effects of cochlear ablation in adulthood with data previously obtained following cochlear ablation in infancy.

Keywords

Auditory Cortex Auditory System Inferior Colliculus Best Frequency Auditory Brainstem Response Threshold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Calford, M.B., Rajan, R. and Irvine, D.R.F. 1993 Rapid changes in the frequency tuning of neurons in cat auditory cortex resulting from pure-tone-induced temporary threshold shift. Neuroscience 55, 953–964.PubMedCrossRefGoogle Scholar
  2. Clarey, J.C., Tweedale, R. and Calford, M.B. (1996) Interhemispheric modulation of somatosensory receptive fields: Evidence for plasticity in primary somatosensory cortex. Cereb Cortex 6, 196–206.PubMedCrossRefGoogle Scholar
  3. Darian-Smith, C. and Gilbert, CD. (1995) Topographic reorganization in the striate cortex of the adult cat and monkey is cortically mediated. J. Neurosci. 15, 1631–1647.PubMedGoogle Scholar
  4. Hashisaki. G.T. and Rubel, E.W (1989) Effects of unilateral cochlea removal on anteroventral cochlear nucleus neurons in developing gerbils. J. Comp. Neurol. 283, 465–473.CrossRefGoogle Scholar
  5. Kelly, J.B., Kavanagh, G.L. and Dalton, J.C.H. (1986a) Hearing in the ferret (Mustela putorius): thresholds for pure tone detection. Hear. Res. 24, 269–275.PubMedCrossRefGoogle Scholar
  6. Kelly, J.B., Judge, P.W. and Phillips, D.P. (1986b) Representation of the cochlea within the primary auditory cortex of the ferret (Mustela putorius). Hear. Res. 24, 111–115.PubMedCrossRefGoogle Scholar
  7. Kelly. J.B. and Judge, P.W. (1994) Binaural organization of primary auditory cortex in the ferret (Mustela putorius). J. Neurophysiol. 71, 904–913.PubMedGoogle Scholar
  8. Kitzes, L.M. (1984) Some physiological consequences of neonatal cochlear destruction in the inferior colliculus of the gerbil, Meriones unguiculatus. Brain Res. 306, 171–178.PubMedCrossRefGoogle Scholar
  9. Kitzes, L.M. and Semple, M.N. (1985) Single-unit responses in the inferior colliculus: effects of neonatal unilateral cochlear ablation. J. Neurophysiol. 53, 1483–500.PubMedGoogle Scholar
  10. Kitzes, L.M., Kageyama, G.H., Semple, M.N. and Kil, J. (1995) Development of ectopic projections from the ventral cochlear nucleus to the superior olivary complex induced by neonatal ablation of the contralateral cochlea. J. Comp. Neurol. 353, 341–363.PubMedCrossRefGoogle Scholar
  11. Moore, D.R. (1990) Auditory brainstem of the ferret: Early cessation of developmental sensitivity to cochlear removal in the cochlear nucleus. J. Comp. Neurol. 302, 810–823.PubMedCrossRefGoogle Scholar
  12. Moore, D.R. (1992) Trophic influences of excitatory and inhibitory synapses on neurones in the auditory brainstem. NeuroReport 3, 269–272.PubMedCrossRefGoogle Scholar
  13. Moore, D.R. (1994) Auditory brainstem of the ferret: Long survival following cochlear removal progressively changes projections from the cochlear nucleus to the inferior colliculus. J. Comp. Neurol. 339, 301–310.PubMedCrossRefGoogle Scholar
  14. Moore, D.R. and Hine, J.E. (1992) Rapid development of auditory brainstem response thresholds in individual ferrets. Dev. Brain Res. 66, 229–235.CrossRefGoogle Scholar
  15. Moore, D.R., King, A.J., McAlpine, D., Martin, R.L. and Hutchings, M.E. (1993) Functional consequences of neonatal cochlear removal. Prog. Brain Res. 97, 127–133.PubMedCrossRefGoogle Scholar
  16. Moore, D. R. and Kitzes, L. M. (1985). Projections from the cochlear nucleus to the inferior colliculus in normal and neonatally, cochlea-ablated gerbils. J. Comp. Neurol. 240, 180–195.PubMedCrossRefGoogle Scholar
  17. Moore, D. R. and Kitzes, L. M. (1986). Cochlear nucleus lesions in the adult gerbil: Effects on neurone responses in the contralateral inferior colliculus. Brain Res. 373, 268–274.PubMedCrossRefGoogle Scholar
  18. Moore, D. R. and Kowalchuk, N. E. (1988) Auditory brainstem of the ferret: Effects of unilateral cochlear lesions on cochlear nucleus volume and projections to the inferior colliculus. J. Comp. Neurol. 272, 503–515.PubMedCrossRefGoogle Scholar
  19. Moore, D.R., Rogers, N.J. and O’Leary, S.J. (1997) Loss of cochlear nucleus neurons following aminoglycoside antibiotics or cochlear removal. Annals Otol. Rhinol. Laryngol., in press.Google Scholar
  20. Moore, D.R. and Pallas, S.L. (1997) Effects of neonatal cochlear removal on neuron size and number in the ferret cochlear nucleus and superior olivary complex. Submitted for publication.Google Scholar
  21. Moore, D. R., Semple, M. N. and Addison, P. D. (1983). Some acoustic properties of neurones in the ferret inferior colliculus. Brain Res. 269, 69–82.PubMedCrossRefGoogle Scholar
  22. Nordeen, K.W., Killackey, H.P. and Kitzes, L.M. (1983) Ascending projections to the inferior colliculus following unilateral cochlear ablation in the neonatal gerbil, Meriones unguiculatus. J. Comp. Neurol. 214, 144–153.PubMedCrossRefGoogle Scholar
  23. Pasic, T.R., Moore, D.R. and Rubel, E.W (1994) The effect of altered neuronal activity on cell size in the medial nucleus of the trapezoid body and ventral cochlear nucleus of the gerbil. J. Comp. Neurol. 348, 111–120.PubMedCrossRefGoogle Scholar
  24. Reale, R.A., Brugge, J.F. and Chan, J.C. (1987) Maps of auditory cortex in cats reared after unilateral cochlear ablation in the neonatal period. Brain Res. 431. 281–290.PubMedGoogle Scholar
  25. Robertson, D. and Irvine. D.R.F. (1989) Plasticity of frequency organization in auditory cortex of guinea pigs with partial unilateral deafness. J. Comp. Neurol. 282, 456–471.PubMedCrossRefGoogle Scholar
  26. Russell, F.A. and Moore, D.R. (1995) Afferent reorganisation within the superior olivary complex of the gerbil: Development and induction by neonatal, unilateral cochlear removal. J. Comp. Neurol. 352, 607–625.PubMedCrossRefGoogle Scholar
  27. Tierney, T.S., Russell, F.A. and Moore, D.R. (1997) Abrupt cessation during early postnatal development of afferent dependent survival of gerbil cochlear nucleus neurons. J. Comp. Neurol., 378, 295–306.PubMedCrossRefGoogle Scholar
  28. Willott, J.F., Aitkin. L.M. and McFadden, S.L. (1993) Plasticity of auditory cortex associated with sensorineural hearing loss in adult C57BL/6J mice. J. Comp. Neurol. 329, 402–411.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • David R. Moore
    • 1
  • Susan J. France
    • 1
  • David McAlpine
    • 1
  • Jennifer E. Mossop
    • 1
  • Huib Versnel
    • 1
  1. 1.University Laboratory of PhysiologyOxfordUK

Personalised recommendations