Reactive Oxygen and Nitrogen Species and Adult Respiratory Distress Syndrome (ARDS): New Mechanisms to be Considered

  • Albert van der Vliet
  • Carroll E. Cross
  • Jason P. Eiserich
Chapter
Part of the NATO ASI Series book series (NSSA, volume 297)

Abstract

The adult respiratory distress syndrome (ARDS) represents a common response of the lung to a variety of different and often unrelated insults, most frequently sepsis, trauma, aspiration and shock. Important consequences are the priming and activation of many components of the inflammatory-immune system accompanied by alterations in the permeability of endothelial and epithelial cell membrane barriers manifest by accumulations of inflammatory pulmonary edema fluid accompanied by phagocyte infiltrations in the interstitial and alveolar compartments of the lung. The net physiologic result is severe hypoxemic acute respiratory failure due to lung ventilation-perfusion mismatching and extensive intrapulmonary shunts. As with inflammatory-immune activation states involving other systems (e.g., rheumatoid arthritis in joints), reactive oxygen species (ROS) and reactive nitrogen species (RNS) are likely to play a significant role in the pathobiology of the lung injury seen in ARDS (Louie et al., 1997; Forni et al., 1997).

Keywords

Permeability Superoxide Respiration Pancreatitis Angiotensin 

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Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • Albert van der Vliet
    • 1
  • Carroll E. Cross
    • 1
  • Jason P. Eiserich
    • 2
  1. 1.Division of Pulmonary/Critical Care MedicineDepartment of Internal Medicine, University of CaliforniaDavisUSA
  2. 2.Department of Anesthesiology, and the Center for Free Radical BiologyUniversity of Alabama at BirminghamBirminghamUSA

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