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Potential Role for Pulmonary Surfactant in Lung Transplantation

  • Fred Possmayer
  • Richard J. Novick
  • Ruud A. W. Veldhuizen
  • John Lee
  • David Bjarneson
  • Jim F. Lewis
Chapter
Part of the NATO ASI Series book series (NSSA, volume 297)

Abstract

Since its introduction in 1954 by Murray and colleagues, allotransplantation has greatly improved the quality, as well as the duration of life for those involved.1 The discovery of immunosuppressant drugs advanced long term efficacy of transplantation and led to a further improvement in the quality of life. Unfortunately, maximal potential benefits have never been achieved. As with a number of other organs, particularly kidneys, livers and hearts, there are lengthy waiting lists for suitable lungs. This lack of sufficient organs results, not only from the limited number of donors, but in part because many of the lungs available for transplant are judged unsuitable, due to edema, aspiration or contusion. The short period over which lungs remain clinically viable, presently 6–8 hours, also limits the availability of these organs. Furthermore, the practice of maintaining brain-damaged potential organ donors on respirators using high oxygen levels and vigorous mechanical ventilation contributes to the paucity of available lungs.

Keywords

Acute Lung Injury Lung Transplantation Left Lung Pulmonary Surfactant Exogenous Surfactant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1998

Authors and Affiliations

  • Fred Possmayer
    • 1
  • Richard J. Novick
    • 2
  • Ruud A. W. Veldhuizen
    • 3
  • John Lee
    • 2
  • David Bjarneson
    • 4
  • Jim F. Lewis
    • 3
  1. 1.Departments of Obstetrics & Gynaecology and Biochemistry and MRC Group in Fetal and Neonatal Health and DevelopmentSan DiegoUSA
  2. 2.Division of Cardiovascular/Thoracic SurgeryDepartment of MedicineSan DiegoUSA
  3. 3.Division of RespirologyDepartment of Medicine The University of Western OntarioLondonCanada
  4. 4.BLES Biochemicals, Inc.LondonCanada

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