Skip to main content
SpringerLink
Log in
Book cover

ADP-Ribosylation in Animal Tissues pp 241–244Cite as

Arginine-Specific Mono(ADP-Ribosyl)Transferase Activity in Human Neutrophil Polymorphs

A Possible Link with the Assembly of Filamentous Actin and Chemotaxis

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 419))

Abstract

Mono(ADP-ribosyl)transferase activity has been detected on the external surface of human polymorphonuclear neutrophil leucocytes (PMNs). The corresponding cDNA has been cloned and shown to be identical to that derived from human skeletal muscle. Our results suggest that mono(ADP-ribosyl)transferase is involved in the transduction pathway mediating (i) receptor-dependent re-alignment of cytoskeletal actin and (ii) chemotaxis of PMNs.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Okazaki, I.J., A. Zolkiewska, M.S. Nightingale & J. Moss. 1994. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. Biochemistry 33: 12828–12836.

    Article  PubMed  CAS  Google Scholar 

  2. Zolkiewska, A., M.S. Nightingale & J. Moss. 1992. Molecular characterization of NAD:arginine ADP-ribosyltransferase from rabbit skeletal muscle. Proc. Natl. Acad. Sci. U-S-A. 89: 11352–11356.

    Article  PubMed  CAS  Google Scholar 

  3. Tsuchiya, M., N. Hara, K. Yamada, H. Osago & M. Shimoyama. 1994. Cloning and expression of cDNA for arginine-specific ADP-ribosyltransferase from chicken bone marrow cells. J. Biol. Chem. 269: 27451–27457.

    PubMed  CAS  Google Scholar 

  4. Davis, T., & S. Shall. 1995. Cloning of a chicken gene homologous to the rabbit mono-ADP-ribosyltransferase gene. Biochem. Soc. Trans. 23: 207S.

    PubMed  CAS  Google Scholar 

  5. Donnelly, L. E., N. B. Rendell, S. Murray, J. R. Allport, G. Lo, P. Kefalas, G. W. Taylor, & J. MacDermot. 1996. Arginine-specific mono(ADP-ribosyl)transferase activity on the surface of human polymorphonuclear neutrophil leucocytes. Biochem. J. 315, 635–641.

    PubMed  CAS  Google Scholar 

  6. Allport, J. R., L. E. Donnelly, B. P. Hayes, S. Murray, N. B. Rendell, K. P. Ray & J. MacDermot. 1996. Reduction by inhibitors of mono(ADP-ribosyl)transferase of chemotaxis in human neutrophil leucocytes by inhibition of the assembly of filamentous actin. Br. J. Pharmacol, (in press).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, Royal Postgraduate Medical School, Du Cane Road, London, W12 0NN, UK

    Panagiotis Kefalas, Jennifer R. Allport, Louise E. Donnelly, Nigel B. Rendell, Stephen Murray, Graham W. Taylor, Gar Lo, Masoud Yadollahi-Farsani & John MacDermot

Authors
  1. Panagiotis Kefalas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jennifer R. Allport
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Louise E. Donnelly
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nigel B. Rendell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Stephen Murray
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Graham W. Taylor
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gar Lo
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Masoud Yadollahi-Farsani
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. John MacDermot
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University Hospital Hamburg-Eppendorf, Hamburg, Germany

    Friedrich Haag  & Friedrich Koch-Nolte  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Kefalas, P. et al. (1997). Arginine-Specific Mono(ADP-Ribosyl)Transferase Activity in Human Neutrophil Polymorphs. In: Haag, F., Koch-Nolte, F. (eds) ADP-Ribosylation in Animal Tissues. Advances in Experimental Medicine and Biology, vol 419. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8632-0_29

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-8632-0_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4652-4

  • Online ISBN: 978-1-4419-8632-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation