Abstract
The RT6 alloantigenic system of the rat was discovered in the 1970s. It was originally designated Pta, AgF, A.R.T.-2, and RTLy-2 by the laboratories involved in its characterization. Exchange of reagents demonstrated that these laboratories had identified the same system, and the official designation RT6 was assigned in 1982 (1).
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Lubaroff, D. M., G. Butcher, C. DeWitt, T. J. Gill, III, E. Günther, J. Howard, and K. Wonigeit. 1983. Fourth international workshop on alloantigenic systems in the rat. Transplant. Proc. 15:1683
Koch, F., A. Kashan, and H.-G. Thiele. 1988. The rat T-cell differentiation marker RT6.1 is more polymorphic than its alloantigenic counterpart RT6.2. Immunology 65:259–265.
Koch, F., H. G. Thiele, and M. G. Low. 1986. Release of the rat T cell alloantigen RT-6.2 from cell membranes by phosphatidylinositol-specific phospholipase C. J. Exp. Med. 164:1338–1343.
Thiele, H.-G., F. Koch, and A. Kashan. 1987. Postnatal distribution profiles of Thy-1+ and RT6+ cells in peripheral lymph nodes of DA rats. Transplant. Proc. 19:3157–3160.
Mojcik, C.R, D. L. Greiner, E. S. Medlock, K. L. Komschlies, and I. Goldschneider. 1988. Characterization of RT6 bearing rat lymphocytes. I. Ontogeny of the RT6+ subset. Cell. Immunol. 114:336–346.
Mojcik, C. R, D. L. Greiner, and I. Goldschneider. 1991. Characterization of RT6-bearing lymphocytes. II. Developmental relationships of RT6 and RT6+ T cells. Develop. Immunol. 1:191–201.
Fangmann, J., R. Schwinzer, and K. Wonigeit. 1991. Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: Predominance of T cell receptor α/β+/CD2 cells and high expression of the RT6 alloantigen. Eur. J. Immunol. 21:753–760.
Waite, D. J., M. C. Appel, E. S. Handler, J. P. Mordes, A. A. Rossini, and D. L. Greiner. 1996. Ontogeny and immunohistochemical localization of thymus dependent and thymus independent RT6+ cells in the rat. Am. J. Pathol. (In Press)
Waite, D. J., E. S. Handler, J. P. Mordes, A. A. Rossini, and D. L. Greiner. 1993. The RT6 rat lymphocyte alloantigen circulates in soluble form. Cell. Immunol. 152:82–95.
Koch, R, R Haag, A. Kashan, and H.-G. Thiele. 1990. Primary structure of rat RT6.2, a nonglycosylated phosphatidylinositol-linked surface marker of postthymic T cells. Proc. Natl. Acad. Sci. USA 87:964–967.
Haag, R, R Koch, and H.-G. Thiele. 1990. Nucleotide and deduced amino acid sequence of the rat T-cell alloantigen RT6.1. Nucleic Acids Res. 18:1047
Hosseinzadeh, H. and I. Goldschneider. 1993. Recent thymic emigrants in the rat express a unique antigenic phenotype and undergo post-thymic maturation in peripheral lymphoid tissues. J. Immunol. 150:1670–1679.
Groen, H., R A. Klatter, N. H. C. Brons, A. S. Wubbena, P. Nieuwenhuis, and J. Kampinga. 1995. High-frequency, but reduced absolute numbers of recent thymic migrants among peripheral blood T lymphocytes in diabetes-prone BB rats. Cell. Immunol. 163:113–119.
Greiner, D. L., J. P. Mordes, M. Angelillo, E. S. Handler, C. R Mojcik, N. Nakamura, and A. A. Rossini. 1988. Role of regulatory RT6+ T-cells in the pathogenesis of diabetes mellitus in BB/Wor rats. In Frontiers in diabetes research: Lessons from animal diabetes II. E. Shafrir and A. E. Renold, editors. John Libbey, London.58–67.
Hunt, H. D. and D. M. Lubaroff. 1992. Identification of functional T cell subsets and surface antigen changes during activation as they relate to RT6. Cell. Immunol. 143:194–211.
Greiner, D. L., J. P. Mordes, E. S. Handler, M. Angelillo, N. Nakamura, and A. A. Rossini. 1987. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant BioBreeding/Worcester (BB/W) rats. J. Exp. Med. 166:461–475.
Fangmann, J., R. Schwinzer, H.-J. Hedrich, I. Klöting, and K. Wonigeit. 1991. Diabetes-prone BB rats express the RT6 alloantigen on intestinal intraepithelial lymphocytes. Eur. J. Immunol. 21:2011–2015.
Fangmann, J., R. Schwinzer, H.-J. Hedrich, and K. Wonigeit. 1993. Demonstration of RT6 expression on a CD3 population of intestinal intraepithelial lymphocytes of athymic nude rats. Transplant. Proc. 25:2789–2790.
Rossini, A. A., J. P. Mordes, E. S. Handler, and D. L. Greiner. 1995. Human autoimmune diabetes mellitus: Lessons from BB rats and NOD mice— Caveat emptor. Clin. Immunol. Immunopathol. 74:2–9.
Mordes, J., R. Bortell, J. Doukas, M. R. Rigby, B. J. Whalen, D. Zipris, D. L. Greiner, and A. A. Rossini. 1996. The BB/Wor rat and the balance hypothesis of autoimmunity. Diabetes/Metab. Rev. (In Press)
Crisá, L., J. P. Mordes, and A. A. Rossini. 1992. Autoimmune diabetes mellitus in the BB rat. Diabetes/Metab. Rev. 8:9–37.
Guberski, D. L. 1994. Diabetes-prone and diabetes-resistant BB rats: Animal models of spontaneous and virally induced diabetes mellitus, lymphocytic thyroiditis, and collagen-induced arthritis. ILAR News 35:29–37.
Greiner, D. L., E. S. Handler, K. Nakano, J. P. Mordes, and A. A. Rossini. 1986. Absence of the RT-6 T cell subset in diabetes-prone BB/W rats. J. Immunol. 136:148–151.
McKeever, U., J. P. Mordes, D. L. Greiner, M. C. Appel, J. Rozing, E. S. Handler, and A. A. Rossini. 1990. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. Proc. Natl. Acad. Sci. USA 87:7718–7722.
Joseph, S., A. G. Diamond, W. Smith, J. D. Baird, and G. W. Butcher. 1993. BB-DR/Edinburgh: A lymphopenic, non-diabetic subline of BB rats. Immunology 78:318–328.
Whalen, B. J., D. L. Greiner, J. P. Mordes, and A. A. Rossini. 1994. Adoptive transfer of autoimmune diabetes mellitus to athymic rats: Synergy of CD4+ and CD8+ T cells and prevention by RT6+ T cells. J. Autoimmun. 7:819–831.
Ellerman, K. and A. Like. 1995.Regulatory T cells in rat autoimmune diabetes are strain dependent. Diabetes 44 (Suppl. l):138A(Abstr.)
Fowell, D. and D. Mason. 1993. Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:621–636.
Bell, E. B. 1992. Function of CD4 T cell subsets in vivo: expression of CD45R isoforms. [Review]. Seminars in Immunology 4:43–50.
Mordes, J. P., D. L. Gallina, E. S. Handler, D. L. Greiner, N. Nakamura, A. Pelletier, and A. A. Rossini. 1987. Transfusions enriched for W3/25+ helper/inducer T lymphocytes prevent spontaneous diabetes in the BB/W rat. Diabetologia 30:22–26.
Zipris, D., D. L. Greiner, S. Malkani, B. J. Whalen, J. P. Mordes, and A. A. Rossini. 1996. Cytokine gene expression in islets and thyroids of BB rats: Interferon gamma and IL-12 p40 mRNA increase with age in both diabetic and insulin treated nondiabetic BB rats. J. Immunol. 156:1315–1321.
Takada, T., K. Iida, and J. Moss. 1994. Expression of NAD glycohydrolase activity by rat mammary adenocarcinoma cells transformed with rat T cell alloantigen RT6.2. J. Biol. Chem. 269:9420–9423.
Haag, F., V. Andresen, S. Karsten, F. Koch-Nolte, and H.-G. Thiele. 1995. Both allelic forms of the rat T cell differentiation marker RT6 display nicotinamide adenine dinucleotide (NAD)-glycohydrolase activity, yet only RT6.2 is capable of automodification upon incubation with NAD. Eur: J. Immunol. 25:2355–2361.
Rigby, M. R., R. Bortell, L. A. Stevens, J. Moss, T. Kanaitsuka, H. Shigeta, J. P. Mordes, D. L. Greiner, and A. A. Rossini. 1996. Rat RT6.2 and mouse Rt6 locus 1 are NAD+:arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity. J. Immunol. (In Press)
Okazaki, I. J. and J. Moss. 1994. Common structure of the catalytic sites of mammalian and bacterial toxin ADP-ribosyltransferases.Mol. Cell Biochem. 138:177–181.
Rashba, E. J., E.-P. Reich, C. A. Janeway, and R. S. Sherwin. 1993. Type 1 diabetes mellitus: an imbalance between effector and regulatory T cells? Acta Diabetol. 30:61–69.
Koch, F., F. Haag, and H.-G. Thiele. 1990. Nucleotide and deduced amino acid sequence for the mouse homologue of the rat T-cell differentiation marker RT6. Nucleic Acids Res. 18:3636
Prochazka, M., H. R. Gaskins, E. H. Leiter, F. Koch-Nolte, F. Haag, and H.-G. Thiele. 1991. Chromosomal localization, DNA polymorphism, and expression of Rt-6, the mouse homologue of rat T-lymphocyte differentiation marker RT6. Immunogenetics 33:152–156.
Koch-Nolte, F., J. Klein, C. Hollmann, M. Kühl, F. Haag, H. R. Gaskins, E. Leiter, and H.-G. Thiele. 1995. Defects in the structure and expression of the genes for the T cell marker Rt6 in NZW and (NZB x NZW)F, mice. Int. Immunol. 7:883–890.
Koch-Nolte, F., D. Petersen, S. Balasubramanian, F. Haag, D. Kahlke, T. Wilier, R. Kastelein, F. Bazan, and H. G. Thiele. 1996. Mouse T cell membrane proteins Rt6-1 and Rt6-2 are arginine protein mono(AD-Pribosyl) transferases and share secondary structure motifs with ADP-ribosylating bacterial toxins. J. Biol. Chem. 271:7686–7693.
Haag, F., F. Koch-Nolte, M. Kühl, S. Lorenzen, and H.-G. Thiele. 1994. Premature stop codons inactivate the RT6 genes of the human and chimpanzee species. J. Mol. Biol. 243:537–546.
Lévy, I., Y. Q. Wu, N. Roeckel, F. Bulle, A. Pawlak, S. Siegrist, M. G. Mattéi, and G. Guellaen. 1996. Human testis specifically expresses a homologue of the rodent T lymphocytes RT6 mRNA. FEBS Lett. 382:276–280.
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Greiner, D.L. et al. (1997). The T Cell Marker RT6 in a Rat Model of Autoimmune Diabetes. In: Haag, F., Koch-Nolte, F. (eds) ADP-Ribosylation in Animal Tissues. Advances in Experimental Medicine and Biology, vol 419. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8632-0_26
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DOI: https://doi.org/10.1007/978-1-4419-8632-0_26
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