Abstract
A human homologue of the rodent T cell mono(ADP-ribosyl)transferase RT6 mRNA was identified by a systematic partial sequencing of human testis transcripts. This messenger encodes for a precursor protein of 367 aa (MW: 41.5 kDa) which exhibits a peptide signal, consensus domains for mono(ADP-ribosyl)transferase and a C terminal part which contains three repeated motives (GEKNQKLEDH) and a region characteristic of glycophosphatidyl inositol anchored proteins. This mRNA is transcribed from a gene localized in 4ql3-q21. Surprisingly, it is not expressed in human white blood cells but it exhibits a very specific testis expression in which it is likely to correspond to a new ADPribosyl transferase.
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© 1997 Springer Science+Business Media New York
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Lévy, I., Pawlak, A., Geneviève Mattei, M., Guellaën, G. (1997). Molecular Cloning and Characterization of A Mono(ADP-Ribosyl)Transferase from Human Testis. In: Haag, F., Koch-Nolte, F. (eds) ADP-Ribosylation in Animal Tissues. Advances in Experimental Medicine and Biology, vol 419. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8632-0_14
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DOI: https://doi.org/10.1007/978-1-4419-8632-0_14
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