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Murine protein kinase CK2: Gene and oncogene

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Book cover A Molecular and Cellular View of Protein Kinase CK2

Part of the book series: Developments in Molecular and Cellular Biochemistry ((DMCB,volume 27))

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Abstract

Protein kinase CK2 (casein kinase II) is a serine-threonine protein kinase with a wide range of substrates, many of which are involved in cell cycle regulation. CK2 activity is elevated in a variety of human tumors and we have used a transgenic mouse model to demonstrate that dysregulated expression of CK2 can induce lymphoma. Thus, CK2 fulfills the definition of an oncogene: A mutated, dysregulated, or mis-expressed gene that contributes to cancer in a dominant fashion. CK2 cooperates in transforming cells with other lymphoid oncogenes such as myc and tal-1, and here we show cooperativity with loss of the tumor suppressor gene p53. To understand more about the physiological and pathological role of CK2, we are cloning the murine CK2α′ cDNA and gene. CK2α′ will be used to generate transgenic and knockout mice and the regulatory elements for gene expression will be analyzed. (Mol Cell Biochem 191: 65–74, 1999)

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Author information

Authors and Affiliations

  1. Department of Medicine, Microbiology, and Pathology, Boston University Medical Center, Boston, MA, USA

    Xin Xu, Esther Landesman-Bollag, Padma L. Channavajhala & David C. Seldin

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  1. Xin Xu
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  2. Esther Landesman-Bollag
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  3. Padma L. Channavajhala
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  4. David C. Seldin
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Editor information

Editors and Affiliations

  1. Cellular and Molecular Biochemistry, Research Laboratory (151) V.A. Medical Centre, One Veterans Drive, Minneapolis, MN, 55417, USA

    Khalil Ahmed

  2. Biokemisk Institut, Odense Universitet, Campusvej 55, DK-5230, Odense M, Denmark

    O. G. Issinger

  3. Laboratoire de Biochemie des Regulations Cellulaires Endocrines, INSERM U244 DBMS, CEA Grenoble, 17 rue des Martyrs, F-38054, Grenoble Cedex 9, France

    E. Chambaz

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Xu, X., Landesman-Bollag, E., Channavajhala, P.L., Seldin, D.C. (1999). Murine protein kinase CK2: Gene and oncogene. In: Ahmed, K., Issinger, O.G., Chambaz, E. (eds) A Molecular and Cellular View of Protein Kinase CK2. Developments in Molecular and Cellular Biochemistry, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8624-5_9

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  • DOI: https://doi.org/10.1007/978-1-4419-8624-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4648-7

  • Online ISBN: 978-1-4419-8624-5

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