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Cathepsins B1 and B2 of Trichobilharzia SPP., Bird Schistosomes Causing Cercarial Dermatitis

  • Martin Kašný
  • Libor Mikeš
  • Kateřina Dolečková
  • Vladimír Hampl
  • Jan Dvořák
  • Marian Novotný
  • Petr Horák
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 712)

Abstract

Trichobilharzia regenti and T. szidati are schistosomes that infect birds. although T. regenti/T. szidati can only complete their life cycle in specific bird hosts (waterfowl), their larvae—cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts (e.g., mouse, man). Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host and include cysteine peptidases such as cathepsins B1 and B2. These enzymes are indispensable bio-catalysts in a number of basal biological processes and host-parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes (T. regenti, T. szidati) and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines.

Keywords

Cysteine Peptidase Schistosoma Mansoni Schistosoma Japonicum Active Site Cleft Cysteine Peptidase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Martin Kašný
    • 1
  • Libor Mikeš
    • 1
  • Kateřina Dolečková
    • 1
  • Vladimír Hampl
    • 1
  • Jan Dvořák
    • 2
  • Marian Novotný
    • 3
  • Petr Horák
    • 1
  1. 1.Department of Parasitology, Faculty of ScienceCharles University in PragueCzech Republic
  2. 2.Institute of ParasitologyBiology Centre of the Academy of Sciences of the Czech RepublicBudějoviceCzech Republic
  3. 3.Department of Cell Biology, Faculty of ScienceCharles University in PraguePragueCzech Republic

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