Cysteine Peptidases of Kinetoplastid Parasites

  • Conor R. Caffrey
  • Ana-Paula Lima
  • Dietmar Steverding
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 712)


We review Clan CA Family C1 peptidases of kinetoplastid parasites (Trypanosoma and Leishmania) with respect to biochemical and genetic diversity, genomic organization and stage-specificity and control of expression. We discuss their contributions to parasite metabolism, virulence and pathogenesis and modulation of the host’s immune response. Their applications as vaccine candidates and diagnostic markers as well as their chemical and genetic validation as drug targets are also summarized.


Cysteine Protease Visceral Leishmaniasis Trypanosoma Cruzi Human African Trypanosomiasis Trypanosoma Brucei 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Conor R. Caffrey
    • 1
  • Ana-Paula Lima
    • 2
  • Dietmar Steverding
    • 3
  1. 1.Sandler Center for Drug Discovery, California Institute for Quantitative Biosciences, Byers HallUniversity of California San FranciscoSan FranciscoUSA
  2. 2.Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de Janeiro, Bloco G, C. C. S., Cidade UniversitáriaIlha do FundãoBrazil
  3. 3.BioMedical Research Centre, School of Medicine, Health Policy and PracticeUniversity of East AngliaNorwichUK

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