Narcolepsy pp 93-104 | Cite as

Prostaglandin D2: An Endogenous Somnogen



The humoral theory of sleep regulation, the concept that sleep and wakefulness are induced and regulated by a hormone-like chemical substance rather than by a neural network, was initially proposed by Kuniomi Ishimori of Nagoya, Japan, in 1909 and independently and concurrently, by a French neuroscientist, Henri Piéron of Paris, in 1913. They took samples of the brain and cerebrospinal fluid (CSF) from sleep-deprived dogs and infused them into the brains of normal dogs.


Prostaglandines Prostaglandine D synthase Adenosine Narcolepsy Ventrolateral preoptic area 



Studies conducted in our laboratory were supported in part by the Program for Promotion of Basic Research Activities for Innovative Biosciences (PROBRAIN); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO); a Health and Labor Science Research Grant from the Ministry of Health, Labor, and Welfare, Japan; and by research grants from Takeda Science Foundation, Takeda Pharmaceutical Co. Ltd., Ono Pharmaceutical Co. Ltd., and Osaka city.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Molecular Behavioral BiologyOsaka Bioscience InstituteSuita-shiJapan

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