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Narcolepsy pp 175–187Cite as

Mathematical Models of Narcolepsy

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Abstract

Mathematical modeling offers a way to critically test experimentally derived theories, integrate experimental results across spatial and temporal scales, and generate predictions to drive bench science and influence clinical practice. Although, in general, mathematical modeling approaches have been applied to narcolepsy only recently, developments in modeling normal sleep/wake behavior have laid an excellent foundation for linking the experimental insights about the orexin (also known as hypocretin) system to the observed features of the narcolepsy phenotype. Thus, many recent models have addressed aspects of narcolepsy including fragmentation of sleep and wake behavior, altered cycling between rapid eye movement (REM) and non-REM (NREM) sleep, sleep onset REM periods (SOREMPs), and cataplexy.

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Authors and Affiliations

  1. Department of Mathematics, University of Michigan, 2074 East Hall, 530 Church Street, Ann Arbor, MI, 48109, USA

    Cecilia Diniz Behn

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  1. Cecilia Diniz Behn
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Correspondence to Cecilia Diniz Behn .

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Editors and Affiliations

  1. , Department of Neurology, University Hospital of Zurich, Frauenklinikstrasse 26, Zurich, 8091, Switzerland

    Christian R. Baumann

  2. Neurocenter EOC of Southern Switzerland, Department of Neurology, University Hospital Zurich, Via Tesserete 46, Lugano, 6903, Switzerland

    Claudio L. Bassetti

  3. and Harvard Medical School, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, 02215, Massachusetts, USA

    Thomas E. Scammell

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Behn, C.D. (2011). Mathematical Models of Narcolepsy. In: Baumann, C., Bassetti, C., Scammell, T. (eds) Narcolepsy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8390-9_16

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  • DOI: https://doi.org/10.1007/978-1-4419-8390-9_16

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