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Gene Electrotransfer to Muscle Tissue: Moving into Clinical Use

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Clinical Aspects of Electroporation

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Abstract

Electrotransfer has been proven as a unique method for gene delivery into tissues. Muscle tissue has been an attractive target due to high efficiency, long-term transgenic expression, and simplicity of the procedure. Gene transfer to muscle is interesting both for vaccination purposes, production of systemic proteins, as well as local correction of myopathies. During the last decade, a large volume of knowledge from rodent studies has accumulated. Presently, the field is moving towards experiments in larger animals and humans where seven clinical trials have been initiated so far. The present review will focus on the knowledge obtained from the preclinical and clinical studies, including the mechanisms and practical considerations when performing muscle electrotransfer both in animals and humans. In addition, the therapeutic applications of muscle electrotransfer will be reviewed.

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Authors and Affiliations

  1. Center of Inflammation and Metabolism at Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark

    Pernille Hojman

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  1. Pernille Hojman
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Correspondence to Pernille Hojman .

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Editors and Affiliations

  1. Division of Interventional Radiology, Department of Radiology, Ronald Reagan Medical Center at UCLA, 757 Westwood Plaza, RM2125, Los Angeles, 90095, California, USA

    Stephen T. Kee

  2. , Department of Oncology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, Herlev, 2730, Denmark

    Julie Gehl

  3. Division of Interventional Radiology, Department of Radiology, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, B2-168 10833, Los Angeles, 90095, California, USA

    Edward W. Lee

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Hojman, P. (2011). Gene Electrotransfer to Muscle Tissue: Moving into Clinical Use. In: Kee, S., Gehl, J., Lee, E. (eds) Clinical Aspects of Electroporation. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8363-3_16

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  • DOI: https://doi.org/10.1007/978-1-4419-8363-3_16

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