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Management: Cirrhotic Portal Hypertension

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Vascular Liver Disease

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Abstract

Gastroesophageal varices are a direct consequence of portal hypertension, the main complication of cirrhosis. An understanding of the pathophysio­logy of portal hypertension has led to significant improvements in the prevention and treatment of variceal hemorrhage. However, variceal hemorrhage continues to carry a significant mortality. By screening all patients with cirrhosis for varices, applying prophylaxis appropriately, actively managing acute variceal hemorrhage, and aggressively preventing recurrence, survival can be improved. Future directions include better risk stratification for a more individualized care, determining the role of noninvasive markers of varices and portal pressure and the development of novel pharmacotherapeutic agents.

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Author information

Authors and Affiliations

  1. Section of Digestive Diseases, Yale University School of Medicine, 333 Cedar Street, LMP 1080, New Haven, CT, 06520, USA

    Guadalupe Garcia-Tsao

  2. Section of Digestive Diseases, VA Connecticut Health Care System, West Haven, CT, USA

    Guadalupe Garcia-Tsao

Authors
  1. Joseph K. Lim
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  2. Guadalupe Garcia-Tsao
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Correspondence to Guadalupe Garcia-Tsao .

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Editors and Affiliations

  1. Keck School of Medicine, Div. GI & Liver Diseases, University of Southern California, Los Angeles, 90033, California, USA

    Laurie D. DeLeve

  2. , Section of Digestive Diseases, Yale University School of Medicine, New Haven, 06520, Connecticut, USA

    Guadalupe Garcia-Tsao

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© 2011 Springer New York

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Lim, J.K., Garcia-Tsao, G. (2011). Management: Cirrhotic Portal Hypertension. In: DeLeve, L., Garcia-Tsao, G. (eds) Vascular Liver Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8327-5_11

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