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Liver, Bile Ducts, and Gallbladder

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Handbook of Practical Immunohistochemistry

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Abstract

The liver is a common site for metastatic tumors, so differentiation of primary from metastatic lesions and identification of site of origin of metastatic tumors are frequent questions faced by pathologists. This chapter focuses on the application of immunohistochemical markers to these questions of hepatic and biliary tumor pathology. Staining profiles are presented for differentiating primary hepatocellular carcinomas, adenoma, and dysplastic nodules. Prognostic markers of hepatocellular adenoma subtypes are described. Challenges of distinguishing intrahepatic cholangiocarcinoma from metastatic mimics are addressed. A unique combination of complimentary markers useful in discriminating reactive from neoplastic epithelium in the gallbladder is shown. A process is defined utilizing an initial screening panel and subsequent confirmatory markers for unknown primary tumors in liver. Photomicrographs illustrate characteristic staining patterns.

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  1. Department of Pathology and Laboratory Medicine, Geisinger Medical Center, 100 North Academy Avenue, Danville, PA, 17822, USA

    Jeffrey Prichard

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  1. Jeffrey Prichard
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  2. Fan Lin
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Correspondence to Jeffrey Prichard .

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  1. , Pathology and Laboratory Medicine, Geisinger Health System, 100 N. Academy Avenue, Danville, 17822, Pennsylvania, USA

    Fan Lin

  2. , Pathology and Laboratory Medicine, Geisinger Medical Center, 100 N. Academy Avenue, Danville, 17822, Pennsylvania, USA

    Jeffrey Prichard

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Prichard, J., Lin, F. (2011). Liver, Bile Ducts, and Gallbladder. In: Lin, F., Prichard, J. (eds) Handbook of Practical Immunohistochemistry. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-8062-5_23

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  • DOI: https://doi.org/10.1007/978-1-4419-8062-5_23

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