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The Role of Histamine in Asthma

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Histamine in Inflammation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 709))

Abstract

Histamine is a ubiquitous inflammatory mediator intimately associated with the pathology of allergy. Traditional antihistamines, targeting the histamine H1 receptor, have failed to demonstrate a significant role for histamine in asthma. Novel immunomodulatory roles for histamine and the discovery of a novel histamine receptor, the histamine H4 receptor, have resulted in a reassessment of its importance in asthma.

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    Paul J. Dunford

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    Robin L. Thurmond PhD

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Dunford, P.J., Holgate, S.T. (2010). The Role of Histamine in Asthma. In: Thurmond, R.L. (eds) Histamine in Inflammation. Advances in Experimental Medicine and Biology, vol 709. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8056-4_6

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