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Gonadotropin-Regulated Testicular Helicase (GRTH/DDX25): A Master Post-transcriptional Regulator of Spermatogenesis

  • Maria L. DufauEmail author
  • Hisashi Sato
  • Ravi Gutti
  • Chon-Hwa Tsai-Morris
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)

Abstract

Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) is a multifunctional protein that is essential for the completion of spermatogenesis. Male mice lacking GRTH are sterile due to the lack of sperm caused by failure of spermatids to elongate. GRTH is a transport protein and as a component of mRNP particles is involved in gene-specific mRNA export (several spermatogenic genes and also its own message) from nuclear to cytoplasmic sites (i.e., chromatoid bodies–mRNA storage/processing and polyribosomes/translation) during spermatogenesis. GRTH is necessary to maintain the structure and function of the chromatoid body in round spermatids. In polyribosomes, GRTH regulates the translation of mRNAs encoding spermatogenic factors. In addition, GRTH prevents germ cell apoptosis. A missense mutation of the GRTH/DDX25 gene associated with the absence of phosphorylated GRTH cytoplasmic species in 5.8% of infertile patients with azoospermia indicates the relevance of GRTH as a post-transcriptional regulator of spermatogenesis

Keywords

Germ Cell Leydig Cell Male Infertility Round Spermatid Infertile Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by the Intramural Research Program of NICHD, National Institutes of Health.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Maria L. Dufau
    • 1
    Email author
  • Hisashi Sato
    • 1
  • Ravi Gutti
    • 1
  • Chon-Hwa Tsai-Morris
    • 1
  1. 1.Program in Developmental Endocrinology and Genetics, Section on Molecular Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of HealthBethesdaUSA

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