Genetic Impact of Both Sex Hormones in Male-Typical Behaviors

  • Takahiro Matsumoto
  • Kazuki Inoue
  • Takashi Sato
  • Shigeaki KatoEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)


Androgens have a critical role in a wide range of biological processes. These include spermatogenesis, development of reproductive organs, and brain function. Most actions of androgens are mediated by the nuclear androgen receptor (AR), which acts as a ligand-inducible transcription factor. To elucidate physiological significance of AR in target tissues, we succeeded in disrupting the AR on the X chromosome using a Cre–loxP system. Male AR-null mutant (ARKO) mice exhibit abnormalities typical of testicular feminization mutants (Tfm), including female external genitalia with atrophic testis [1]. They also develop late-onset obesity [2] with glucocorticoid overproduction [3] and impaired bone growth coupled with high bone turnover [4]. Moreover, essential role of AR for normal folliculogenesis suggests that androgen/AR signaling is also physiologically important in females [5]. On the other hand, the physiological role of AR-mediated androgen signaling in brain masculinization has not been established. We describe here the cooperative role of sex hormones signaling in brain sex differences underlying the expression of male-typical behaviors.


Androgen Receptor Androgen Receptor Gene High Bone Turnover Male Sexual Behavior Female External Genitalia 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Takahiro Matsumoto
    • 1
  • Kazuki Inoue
    • 1
  • Takashi Sato
    • 1
  • Shigeaki Kato
    • 1
    Email author
  1. 1.Laboratory of Nuclear SignalingInstitute of Molecular and Cellular Biosciences, The University of TokyoTokyoJapan

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