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Genetic Impact of Both Sex Hormones in Male-Typical Behaviors

  • Takahiro Matsumoto
  • Kazuki Inoue
  • Takashi Sato
  • Shigeaki KatoEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)

Abstract

Androgens have a critical role in a wide range of biological processes. These include spermatogenesis, development of reproductive organs, and brain function. Most actions of androgens are mediated by the nuclear androgen receptor (AR), which acts as a ligand-inducible transcription factor. To elucidate physiological significance of AR in target tissues, we succeeded in disrupting the AR on the X chromosome using a Cre–loxP system. Male AR-null mutant (ARKO) mice exhibit abnormalities typical of testicular feminization mutants (Tfm), including female external genitalia with atrophic testis [1]. They also develop late-onset obesity [2] with glucocorticoid overproduction [3] and impaired bone growth coupled with high bone turnover [4]. Moreover, essential role of AR for normal folliculogenesis suggests that androgen/AR signaling is also physiologically important in females [5]. On the other hand, the physiological role of AR-mediated androgen signaling in brain masculinization has not been established. We describe here the cooperative role of sex hormones signaling in brain sex differences underlying the expression of male-typical behaviors.

Keywords

Androgen Receptor Androgen Receptor Gene High Bone Turnover Male Sexual Behavior Female External Genitalia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Takahiro Matsumoto
    • 1
  • Kazuki Inoue
    • 1
  • Takashi Sato
    • 1
  • Shigeaki Kato
    • 1
    Email author
  1. 1.Laboratory of Nuclear SignalingInstitute of Molecular and Cellular Biosciences, The University of TokyoTokyoJapan

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