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Angiotensin AT2 Receptors: Control of Renal Sodium Excretion and Blood Pressure

  • Robert M. CareyEmail author
Conference paper
  • 1.2k Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)

Abstract

Angiotensin (Ang) II, the primary transducer peptide of the renin–Ang system (RAS), acts at two major receptors: type 1 (AT1R) and type 2 (AT2R). The majority of Ang II actions occur via AT1Rs, including antinatriuresis. Renal cross-transplantation studies have demonstrated that renal AT1Rs are both necessary and sufficient for the induction and sustainability of hypertension during Ang II infusion and that increased Na+ reabsorption in the renal proximal tubule (RPT) is the major determinant of this response. In contrast, the role of AT2Rs in the control of Na+ excretion and hypertension has not been defined. AT2Rs are expressed in the adult kidney predominantly in RPT cells.

Keywords

Renal Proximal Tubule Apical Plasma Membrane Adult Kidney Renal Proximal Tubule Cell Natriuretic Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Endocrinology and MetabolismUniversity of Virginia Health SystemCharlottesvilleUSA

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