Angiotensin AT2 Receptors: Control of Renal Sodium Excretion and Blood Pressure

  • Robert M. CareyEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)


Angiotensin (Ang) II, the primary transducer peptide of the renin–Ang system (RAS), acts at two major receptors: type 1 (AT1R) and type 2 (AT2R). The majority of Ang II actions occur via AT1Rs, including antinatriuresis. Renal cross-transplantation studies have demonstrated that renal AT1Rs are both necessary and sufficient for the induction and sustainability of hypertension during Ang II infusion and that increased Na+ reabsorption in the renal proximal tubule (RPT) is the major determinant of this response. In contrast, the role of AT2Rs in the control of Na+ excretion and hypertension has not been defined. AT2Rs are expressed in the adult kidney predominantly in RPT cells.


Renal Proximal Tubule Apical Plasma Membrane Adult Kidney Renal Proximal Tubule Cell Natriuretic Response 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Endocrinology and MetabolismUniversity of Virginia Health SystemCharlottesvilleUSA

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