Angiotensin AT2 Receptors: Control of Renal Sodium Excretion and Blood Pressure
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Angiotensin (Ang) II, the primary transducer peptide of the renin–Ang system (RAS), acts at two major receptors: type 1 (AT1R) and type 2 (AT2R). The majority of Ang II actions occur via AT1Rs, including antinatriuresis. Renal cross-transplantation studies have demonstrated that renal AT1Rs are both necessary and sufficient for the induction and sustainability of hypertension during Ang II infusion and that increased Na+ reabsorption in the renal proximal tubule (RPT) is the major determinant of this response. In contrast, the role of AT2Rs in the control of Na+ excretion and hypertension has not been defined. AT2Rs are expressed in the adult kidney predominantly in RPT cells.