Biology and Genetics of Anti-Müllerian Hormone
Anti-Müllerian hormone (AMH) also known as Müllerian inhibiting substance (MIS) is a homodimeric glycoprotein selectively involved in reproduction and development. As shown by Cate et al. , it belongs to the TGF-β family, with homology essentially to the BMP proteins. Like all members of the family, it is composed of a long N-terminus, which must be cleaved from the short C-terminus for biological activity. The N-terminus is inactive on its own but plays a role in folding and helps the C-terminus cross the cell membrane and get secreted. A 3D putative model of the AMH C-terminus has been constructed by analogy with crystallized membersof the BMP family .
KeywordsAndrogen Receptor Inguinal Hernia Granulosa Cell Sertoli Cell Primordial Follicle
- 1.Cate, R. L., Mattaliano, R. J., Hession, C., Tizard, R., Farber, N. M., Cheung, A., Ninfa, E. G., Frey, A. Z., Gash, D. J., Chow, E. P., Fisher, R. A., Bertonis, J. M., Torres, G., Wallner, B. P., Ramachandran, K. L., Ragin, R. C., Manganaro, T. F., MacLaughlin, D. T., and Donahoe, P. K. (1986) Cell 45, 685–698PubMedCrossRefGoogle Scholar