Biology and Genetics of Anti-Müllerian Hormone
Anti-Müllerian hormone (AMH) also known as Müllerian inhibiting substance (MIS) is a homodimeric glycoprotein selectively involved in reproduction and development. As shown by Cate et al. , it belongs to the TGF-β family, with homology essentially to the BMP proteins. Like all members of the family, it is composed of a long N-terminus, which must be cleaved from the short C-terminus for biological activity. The N-terminus is inactive on its own but plays a role in folding and helps the C-terminus cross the cell membrane and get secreted. A 3D putative model of the AMH C-terminus has been constructed by analogy with crystallized membersof the BMP family .
KeywordsTestosterone Androgen Infertility Cryptorchidism PMDS
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