Apparent Mineralocorticoid Excess – Update

  • Saroj NimkarnEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)


Apparent mineralocorticoid excess (AME) is a rare inherited form of hypertension caused by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD) deficiency. The disorder was first described biochemically and hormonally in 1977 by New et al. in a Native American girl with severe hypertension [1]. The syndrome is caused by non-functional mutations in HSD11B2 on chromosome16q22. More than 40 causative mutations have been described. AME defined an important “pre-receptor” pathway in steroid hormone action and their specificities to the receptor.


Mineralocorticoid Receptor Severe Hypertension Causative Mutation Metabolite Ratio Tritiated Water 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.New York-Presbyterian Hospital, Weill Cornell Medical CollegeNew YorkUSA

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