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Apparent Mineralocorticoid Excess – Update

  • Saroj NimkarnEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 707)

Abstract

Apparent mineralocorticoid excess (AME) is a rare inherited form of hypertension caused by 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD) deficiency. The disorder was first described biochemically and hormonally in 1977 by New et al. in a Native American girl with severe hypertension [1]. The syndrome is caused by non-functional mutations in HSD11B2 on chromosome16q22. More than 40 causative mutations have been described. AME defined an important “pre-receptor” pathway in steroid hormone action and their specificities to the receptor.

Keywords

Mineralocorticoid Receptor Severe Hypertension Causative Mutation Metabolite Ratio Tritiated Water 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.New York-Presbyterian Hospital, Weill Cornell Medical CollegeNew YorkUSA

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