Skip to main content
SpringerLink
Log in

Relevance of the Cutaneous Vitamin D Endocrine System for Skin Physiology and Treatment of Skin Diseases

  • Chapter
  • First Online:
Nutrition and Skin

  • 2682 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Adachi Y, Uchida N, Matsuo T, Horio T. Clinical effect of vitamin D3 analogues is not inactivated by subsequent UV exposure. Photodermatol Photoimmunol Photomed. 2008;24(1):16–8.

    Article  PubMed  CAS  Google Scholar 

  • Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med. 2001;344:975–83.

    Article  PubMed  CAS  Google Scholar 

  • Amano H, Abe M, Ishikawa O. First case report of topical tacalcitol for vitiligo repigmentation. Pediatr Dermatol. 2008;25(2):262–4.

    Article  PubMed  Google Scholar 

  • Bielawska A, Linardic CM, Hannun YA. Modulation of cell growth and differentiation by ceramide. FEBS Lett. 1992;307:211–4.

    Article  PubMed  CAS  Google Scholar 

  • Bikle DD, Neumanic MK, Gee E, Elias P. 1, 25-Dihydroxyvitamin D3 production by human keratinocytes. J Clin Invest. 1986;78:557–66.

    Article  PubMed  CAS  Google Scholar 

  • Bikle DD, Halloran BP, Riviere JE. Production of 1, 25-Dihydroxyvitamin D3 by perfused pig skin. J Clin Invest. 1994;102:796–8.

    CAS  Google Scholar 

  • Bottomley JM, Auland ME, Morais J, Boyd G, Douglas WS. Cost-effectiveness of the two-compound formulation calcipotriol and betamethasone dipropionate compared with commonly used topical treatments in the management of moderately severe plaque psoriasis in Scotland. Curr Med Res Opin. 2007;23(8):1887–901.

    Article  PubMed  Google Scholar 

  • Cambazard, van de Kerkhof PCM, Hutchinson PE, and the Calcipotriol Study Group. 1996. Proceedings of the 3 rd International Calcipotriol Symposium, Munich, Germany, 23 March 1996.

    Google Scholar 

  • Colston KW, Chander SK, Mackay AG, Coombes RC. Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro. Biochem Pharmacol. 1992;44:693–702.

    Article  PubMed  CAS  Google Scholar 

  • De Haes P, Garmyn M, Degreef H, Vantieghem K, Bouillon R, Segaert S. 1, 25-dihydroxyvitamin D3 inhibits ultraviolet B induced apoptosis, jun kinase activation, and interleukin-6 production in primary human keratinocytes. J Cell Biochem. 2003;89:663–73.

    Article  PubMed  Google Scholar 

  • De Haes P, Garmyn M, Verstuyf A, De Clercq P, Vandewalle M, Vantieghem K, et al. Two 14-epi analogues of 1, 25-dihydroxyvitamin D3 protect human keratinocytes against the effects of UVB. Arch Dermatol Res. 2004;295:527–34.

    Article  PubMed  Google Scholar 

  • De Haes P, Garmyn M, Verstuyf A, De Clercq P, Vandewalle M, Degreef H, Vantieghem K, Bouillon R, Segaert S. 1, 25(OH)2D3 and analogues protect primary human keatinocytes against UVB-induced DNA damage. 2005.

    Google Scholar 

  • De Korte J, van der Valk PG, Sprangers MA, Damstra RJ, Kunkeler AC, Lijnen RL, et al. A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: quality-of-life outcomes of a randomized controlled trial of supervised treatment of psoriasis in a day-care setting. Br J Dermatol. 2008;158(2):375–81.

    Article  PubMed  Google Scholar 

  • Eisman JA, Barkla DH, Tutton PJM. Suppression of in vivo growth of human cancer solid tumor xenografts by 1α,25-dihydroxyvitamin D3. Cancer Res. 1987;47:21–5.

    PubMed  CAS  Google Scholar 

  • Elwood JM, Jopson J. Melanoma and sun exposure: an overview of published studies. Int J Cancer. 1997;73:198–203.

    Article  PubMed  CAS  Google Scholar 

  • Ezquerra GM, Regana MS, Millet PU. Combination of acitretin and oral calcitriol for treatment of plaque-type psoriasis. Acta Derm Venereol. 2007;87(5):449–50.

    Article  PubMed  Google Scholar 

  • Franceschi RT, Linson CJ, Peter CT, Romano PR. Regulation of cellular adhesion and fibronectin synthesis by 1α,25-dihydroxyvitamin D3. J Biol Chem. 1987;262:4165–71.

    PubMed  CAS  Google Scholar 

  • Fu GK, Lin D, Zhang MY, Bikle DD, Shackleton CH, Miller WL, et al. Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1. Mol Endocrinol. 1997;11:1961–70.

    Article  PubMed  CAS  Google Scholar 

  • Geilen CC, Bektas M, Wieder T, Orfanos CR. 1α,25-Dihydroxyvitamin D3 induces sphingomyelin hydrolysis in HaCaT cells via tumor necrosis factor α. J Biol Chem. 1997;272:8997–9001.

    Article  PubMed  CAS  Google Scholar 

  • Gniadecki R. Stimulation versus inhibition of keratinocyte growth by 1,25-Dihydroxyvitamin D3: dependence on cell culture conditions. J Invest Dermatol. 1996;106(3):510–6.

    Article  PubMed  CAS  Google Scholar 

  • Goldinger SM, Dummer R, Schmid P, Burg G, Seifert B, Läuchli S. Combination of 308-nm xenon chloride excimer laser and topical calcipotriol in vitiligo. J Eur Acad Dermatol Venereol. 2007;21(4):504–8.

    PubMed  CAS  Google Scholar 

  • Gombard HF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J. 2005;19(9):1067–77.

    Article  Google Scholar 

  • Gray JD, Bottomley W, Layton AM, Cotterill JA, Monteiro E. The use of calcipotriol in HIV-related psoriasis. Clin Exp Dermatol. 1992;17(5):342–3.

    Article  PubMed  CAS  Google Scholar 

  • Green C, Ganpule M, Harris D, Kavanagh G, Kennedy C, Mallett R, et al. Comparative effects of calcipotriol (MC 903) solution and placebo (vehicle of MC 903) in the treatment of psoriasis of the scalp. Br J Dermatol. 1994;130:483–7.

    Article  PubMed  CAS  Google Scholar 

  • Griffin M, Kumar R. Effects of 1α,25-Dihydroxyvitamin D3 and its analogs on dendritic cell function. J Cell Biochem. 2003;88:323–6.

    Article  PubMed  CAS  Google Scholar 

  • Grossman RM, Thivolet J, Claudy A, Souteyrand P, Guilhou JJ, Thomas P, et al. A novel therapeutic approach to psoriasis with combination calcipotriol ointment and very low-dose cyclosporine: a result of a multicenter placebo-controlled study. J Am Acad Dermatol. 1994;31:68–74.

    Article  PubMed  CAS  Google Scholar 

  • Gupta R, Dixon KM, Deo SS, Holliday CJ, Slater M, Halliday GM, et al. Photoprotection by 1, 25-Dihydroxyvitamin D3 is associated by an increase in p53 and a decrease in nitric oxide products. J Invest Dermatol. 2006;127:707–15.

    Article  PubMed  Google Scholar 

  • Hanada K, Sawamura D, Nakano H, Hashimoto I. Possible role of 1,25-dihydroxyvitamin D3 –induced metallothionein in photoprotection against UVB injury in mouse skin and cultured rat keratinocytes. J Dermatol Sci. 1995;9:203–8.

    Article  PubMed  CAS  Google Scholar 

  • Helfrich YR, Kang S, Hamilton TA, Voorhees JJ. Topical becocalcidiol for the treatment of psoriasis vulgaris: a randomized, placebo-controlled, double-blind, multicentre study. Br J Dermatol. 2007;157(2):369–74.

    Article  PubMed  CAS  Google Scholar 

  • Holick MF. Photobiology, physiology and clinical applications for vitamin D. In: Goldsmith LA, editor. Physiology, biochemistry and molecular biology of the skin. 2nd ed. New York: Oxford University Press; 1991. p. 928–56.

    Google Scholar 

  • Holick MF. Evolution and function of vitamin D. Recent Results Cancer Res. 2003;164:3–28.

    PubMed  CAS  Google Scholar 

  • Holick MF. Vitamin D deficiency. NEJM. 2007;357:266–81.

    Article  PubMed  CAS  Google Scholar 

  • Holick MF, Reichrath J. Clinical utility of 1,25-dihydroxyvitamin D3 and its analogues for the treatment of psoriasis. In: Holick MF, editor. Vitamin D: physiology, molecular biologic and clinical aspects. Totowa: The Humana Press Inc; 1999. p. S357–73.

    Google Scholar 

  • Holick MF, Chen ML, Kong XF, Sanan DK. Clinical uses for calciotropic hormones 1,25-dihydroxyvitamin D3 and parathyroid hormone related peptide in dermatology: a new perspective. J Invest Dermatol Symp Proc. 1996;1:1–9.

    CAS  Google Scholar 

  • Humbert P, Dupond JL, Agache P, Laurent R, Rochefort A, Drobacheff C, et al. Treatment of scleroderma with oral 1,25-dihydroxyvitamin D3: evaluation of skin involvement using non-invasive techniques. Results of an open prospective trial. Acta Derm Venereol Stockh. 1993;73:449–51.

    PubMed  CAS  Google Scholar 

  • Katayama I, Minatohara K, Yokozeki H, Nishioka K. Topical vitamin D3 downregulates IgE-mediated murine biphasic cutaneous reactions. Int Arch Allergy Immunol 1996;111(1):71–6.

    Google Scholar 

  • Kerscher M, Volkenandt M, Plewig G, Lehmann P. Combination phototherapy of psoriasis with calcipotriol and narrow band UVB. Lancet. 1993;342:923.

    Article  PubMed  CAS  Google Scholar 

  • Koeffler HP, Hirji K, Itri L. 1,25-dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells. Cancer Treat Rep. 1985;69:1399–407.

    PubMed  CAS  Google Scholar 

  • Kragballe K. Combination of topical calcipotriol (MC 903) and UVB radiation for psoriasis vulgaris. Dermatologica. 1990;181:211–4.

    Article  PubMed  CAS  Google Scholar 

  • Kragballe K, Beck HI, Sogaard H. Improvement of psoriasis by topical vitamin D3 analogue (MC 903) in a double-blind study. Br J Dermatol. 1988;119:223–30.

    Article  PubMed  CAS  Google Scholar 

  • Kragballe K, Gjertsen BT, de Hoop D, Karlsmark T, van de Kerhof PCM, Larko O, et al. Double-blind right/left comparison of calcipotriol and betametasone valerate in treatment of psoriasis vulgaris. Lancet. 1991;337:193–6.

    Article  PubMed  CAS  Google Scholar 

  • Kragballe K, Barnes L, Hamberg KJ, Hutchinson P, Murphy F, Moller S, et al. Calcipotriol cream with or without concurrent topical corticosteroid in psoriasis: Tolerability and efficacy. Br J Dermatol. 1998;139:649–54.

    Article  PubMed  CAS  Google Scholar 

  • Kricker A, Armstrong BK, English DR. Sun exposure and non-melanocytic skin cancer. Cancer Causes Control. 1994;5:367–92.

    Article  PubMed  CAS  Google Scholar 

  • Kumaran MS, Kaur I, Kumar B. Effect of topical calcipotriol, betamethasone dipropionate and their combination in the treatment of localized vitiligo. J Eur Acad Dermatol Venereol. 2006;20(3):269–73.

    Article  PubMed  CAS  Google Scholar 

  • Lee JH, Youn JI. The photoprotective effect of 1, 25-Dihydroxyvitamin D3 on ultraviolet B-induced damage in keratinocyte and its mechanisms of action. J Dermatol Sci. 1998;18:11–8.

    Article  PubMed  CAS  Google Scholar 

  • Lehmann B, Tiebel O, Meurer M. Expression of vitamin D3 25-hydroxylase (CYP27) mRNA after induction by vitamin D3 or UVB radiation in keratinocytes of human skin equivalents-a preliminary study. Arch Dermatol Res. 1999;291:507–10.

    Article  PubMed  CAS  Google Scholar 

  • Lehmann B, Genehr T, Knuschke P, Pietsch J, Meurer M. UVB-induced conversion of 7-dehydrocholesterol to 1alpha25-dihydroxyvitamin D3 in an in vitro human skin equivalent model. J Invest Dermatol. 2001;117:1179–85.

    Article  PubMed  CAS  Google Scholar 

  • Liao YH, Chiu HC, Tseng YS, Tsai TF. Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(−1) ointment and tacrolimus 0.3 mg g(−1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trial. Br J Dermatol. 2007;157(5):1005–12.

    Article  PubMed  CAS  Google Scholar 

  • Lucker GP, van de Kerkhof PC, van Dijk MR, Steijlen PM. Effect of topical calcipotriol on congenital ichthyosis. Br J Dermatol. 1994;131:546–50.

    Article  PubMed  CAS  Google Scholar 

  • MacLaughlin JA, Gange W, Taylor D, Smith E, Holick MF. Cultured psoriatic fibroblasts from involved and uninvolved sites have partial but not absolute resistance to the proliferation-­inhibition activity of 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA. 1985;82:5409–12.

    Article  PubMed  CAS  Google Scholar 

  • Manggau M, Kim DS, Ruwisch L, Vogler R, Korting HC. 1α,25-Dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol. 2001;117:1241–9.

    Article  PubMed  CAS  Google Scholar 

  • Morimoto S, Kumahara Y. A patient with psoriasis cured by 1α-hydroxyvitamin D3. Med J Osaka Univ. 1985;35(3–4):51–4.

    PubMed  CAS  Google Scholar 

  • Morimoto S, Yochikawa K, Kozuka T, Kitano Y, Imawaka S, Fukuo K, Koh E, Kumahara Y. An open study of vitamin O3 treatment in psoriasis vulgaris. Br J Dermatol 1986;115:421–9.

    Google Scholar 

  • Okasaki T, Bell RM, Hannun YA. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem. 1989;264:19076–80.

    Google Scholar 

  • Ortonne JP. Calcipotriol in combination with betametasone diproprionate. Nouv Dermatol. 1994;13:736–51.

    Google Scholar 

  • Osterlind A, Tucker MA, Stone BJ, Jensen OM. The Danish case-control study of cutaneous malignant melanoma. II Importance of UV-light exposure. Int J Cancer. 1988;42:319–24.

    Article  PubMed  CAS  Google Scholar 

  • Perez A, Chen TC, Turner A, Holick MF. Pilot study of topical calcitriol (1,25-dihydroxyvitamin D3) for treating psoriasis in children. Arch Dermatol. 1995;131:961–2.

    Article  PubMed  CAS  Google Scholar 

  • Perez A, Chen TC, Turner A, Raab R, Bhawan J, Poche P, et al. Efficacy and safety of topical calcitriol (1,25-dihydroxyvitamin D3) for the treatment of psoriasis. Br J Dermatol. 1996a;134:238–46.

    Article  PubMed  CAS  Google Scholar 

  • Perez A, Raab R, Chen TC, Turner A, Holick MF. Safety and efficacy of oral calcitriol (1,25-dihydroxyvitamin D3) for the treatment of psoriasis. Br J Dermatol. 1996b;134:1070–8.

    Article  PubMed  CAS  Google Scholar 

  • Petrow W. Treatment of a nail psoriasis with calcipotriol. Akt Dermatol. 1995;21:396–400.

    Google Scholar 

  • Reichrath J. The challenge resulting from positive and negative effects of sunlight: how much solar UV-exposure is appropriate to balance between risks of vitamin D deficiency and skin cancer? Prog Biophys Mol Biol. 2006;92:9–16.

    Article  PubMed  CAS  Google Scholar 

  • Reichrath J, Müller SM, Kerber A, Baum HP, Bahmer FA. Biologic effects of topical calcipotriol (MC 903) treatment in psoriatic skin. J Am Acad Dermatol. 1997a;36:19–28.

    Article  PubMed  CAS  Google Scholar 

  • Reichrath J, Perez A, Chen TC, Kerber A, Bahmer FA, Holick MF. The effectiveness of topical 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) application in the treatment of psoriasis: an immunohistological evaluation. Acta Derm Venereol. 1997b;77:268–72.

    PubMed  CAS  Google Scholar 

  • Saggese G, Federico G, Battini R. Topical application of 1,25 dihydroxyvitamin D3 (calcitriol) is an effective and reliable therapy to cure skin lesions in psoriatic children. Eur J Pediatr. 1993;152:389–92.

    Article  PubMed  CAS  Google Scholar 

  • Serup J. Calcipotriol irritation: mechanism, diagnosis and clinical implication. Acta Derm Venereol (Stockh) Abstract. 1994;186:42S.

    Google Scholar 

  • Sigmundsdottir H, Pan J, Debes GF, Alt C, Habtezion A, Soler D, Butcher EC. DCS metabolize sunlight–induced vitamin D3 to “program” T cell attraction to the epidermal chemokine CCL27. Nat Immunol 2007;8(3):285–93.

    Google Scholar 

  • Solvoll K, Soyland E, Sandstad B, Drevon CA. Dietary habits among patients with atopic dermatitis. Eur J Clin Nutr. 2000;54(2):93–7.

    Article  PubMed  CAS  Google Scholar 

  • Texereau M, Viac J. Vitamin D, immune system and skin. Eur J Dermatol. 1992;2:258–64.

    CAS  Google Scholar 

  • Toole JW. Calcipotriol and betamethasone dipropionate for the treatment of psoriasis: a 52-week study. Skin Therapy Lett. 2007;12(4):1–3.

    PubMed  CAS  Google Scholar 

  • Trémezaygues L. In vitro Untersuchungen in humanen Keratinozyten über mögliche protektive Eigenschaften von 1,25-dihydroxyvitamin D3 gegen UVB- und niedrigdosierte ionisierende Strahlung. 2009.

    Google Scholar 

  • Tzaneva S, Hönigsmann H, Tanew A. Observer-blind, randomized, intrapatient comparison of a novel 1% coal tar preparation (Exorex R) and calcipotriol cream in the treatment of plaque type psoriasis. Br J Dermatol. 2003;149:350–3.

    Article  PubMed  CAS  Google Scholar 

  • Van de Kerkhof PC, Vissers WH. The topical treatment of psoriasis. Skin Pharmacol Appl Skin Physiol. 2003;16:69–83.

    PubMed  Google Scholar 

  • van de Kerkhof PCM, van Bokhoven M, Zultak M, Czarnetzki BM. A double-blind study of topical 1α-25-dihydroxyvitamin D3 in psoriasis. Br J Dermatol. 1989;120:661–4.

    Article  PubMed  Google Scholar 

  • Weber G, Heilborn JD, Chamorro Jimenez CI, Hammarsjö A, Törmä H, Ståhle M. Vitamin D induces the antimicrobial protein hCAP18 in human skin. J Invest Dermatol. 2005;124(5):1080–2.

    Article  PubMed  CAS  Google Scholar 

  • Zhu X, Wang B, Zhao G, Gu J, Chen Z, Briantais P, et al. An investigator-masked comparison of the efficacy and safety of twice daily applications of calcitriol 3 microg/g ointment vs. calcipotriol 50 microg/g ointment in subjects with mild to moderate chronic plaque-type psoriasis. J Eur Acad Dermatol Venereol. 2007;21(4):466–72.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, The Saarland University Hospital, Kirrberger Strasse, 66421, Homburg/Saar, Germany

    Léa Trémezaygues

  2. Department of Dermatology, The Saarland University Hospital, Homburg/Saar, Germany

    Jörg Reichrath

Authors
  1. Léa Trémezaygues
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jörg Reichrath
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Léa Trémezaygues .

Editor information

Editors and Affiliations

  1. Johnson & Johnson, Grandview Road 199, Skillman, 08558, New Jersey, USA

    Apostolos Pappas

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Trémezaygues, L., Reichrath, J. (2011). Relevance of the Cutaneous Vitamin D Endocrine System for Skin Physiology and Treatment of Skin Diseases. In: Pappas, A. (eds) Nutrition and Skin. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7967-4_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-7967-4_3

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-7966-7

  • Online ISBN: 978-1-4419-7967-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation