Drug–Drug Interactions: Designing Development Programs and Appropriate Product Labeling

  • J. Matthew Hutzler
  • Jack Cook
  • Joseph C. Fleishaker


Drug–drug interactions can represent a major public health issue. Drug metabolism science has evolved to the point where interactions with cytochrome P-450 isozymes can be predicted and potentially avoided or managed, but much work remains to allow accurate prediction of non-P-450 mediated interactions. Based on preclinical data, rational clinical plans can be developed to study potential drug–drug interactions in humans and develop labeling that allows optimal usage of new drugs.


Human Liver Microsome Constitutive Androstane Receptor Probe Substrate Drug Interaction Study Tienilic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© American Association of Pharmaceutical Scientists 2011

Authors and Affiliations

  • J. Matthew Hutzler
  • Jack Cook
  • Joseph C. Fleishaker
    • 1
  1. 1.Pfizer, St. Louis Laboratories, Clinical ResearchSt. LouisUSA

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