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7TM-Cadherins: Developmental Roles and Future Challenges

  • Chapter
Adhesion-GPCRs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 706))

Abstract

The 7TM-Cadherins, Celsr/Flamingo/Starry night, represent a unique subgroup of adhesion-GPCRs containing atypical cadherin repeats, capable of homophilic interaction, linked to the archetypal adhesion-GPCR seven-transmembrane domain. Studies in Drosophila provided a first glimpse of their functional properties, most notably in the regulation of planar cell polarity (PCP) and in the formation of neural architecture. Many of the developmental functions identified in flies are conserved in vertebrates with PCP predicted to influence the development of multiple organ systems. Details of the molecular and cellular functions of 7TM-Cadherins are slowly emerging but many questions remain unanswered. Here the developmental roles of 7TM-Cadherins are discussed and future challenges in understanding their molecular and cellular roles are explored.

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  1. MRC Centre for Developmental Neurobiology, New Hunt’s House, Guy’s Campus, King’s College London, SE1 1UL, UK

    Caroline J. Formstone

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  1. Caroline J. Formstone
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  1. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Simon Yona PhD

  2. Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

    Martin Stacey DPhil

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Formstone, C.J. (2010). 7TM-Cadherins: Developmental Roles and Future Challenges. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_2

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