Abstract
The male reproductive tract expresses a diverse array of adhesion-GPCRs, many in a highly specific and regulated manner. Despite this specificity of expression, little is known about the function of this receptor family in male reproductive physiology. Insights into function are beginning to emerge with the increasing availability of genetically modified mice harbouring mutations in these genes. Gpr64 is the best characterised of the adhesion-GPCRs in the male reproductive system and the phenotype of Gpr64 knock-out mice implicates this receptor in the regulation of fluid absorption in the efferent ducts and proximal epididymis. This chapter summarizes recent data concerning this receptor and other family members in the male reproductive system.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Divina P, Vlcek C, Stmad P et al. Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics 2005; 6(1):29.
Johnston DS, Jelinsky SA, Bang HJ et al. The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymis. Biol Reprod 2005; 73(3):404–413.
Bjarnadottir TK, Fredriksson R, Hoglund PJ et al. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004; 84(1):23–33.
Haitina T, Olsson F, Stephansson O et al. Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat. BMC Neurosci 2008; 9:43.
Osterhoff C, Ivell R, Kirchhoff C. Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily. DNA Cell Biol 1997; 16(4):379–389.
Obermann H, Samalecos A, Osterhoff C et al. HE6, atwo-subunit heptahelical receptor associated with apical membranes of efferent and epididymal duct epithelia. Mol Reprod Dev 2003; 64(1):13–26.
Bjarnadottir TK, Fredriksson R, Schioth HB. The adhesion GPCRs: a unique family of G protein-coupled receptors with important roles in both central and peripheral tissues. Cell Mol Life Sci 2007; 64(16):2104–2119.
Xu L, Begum S, Hearn JD et al. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2 and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci USA 2006; 103(24):9023–9028.
Wang T, Ward Y, Tian L et al. CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells. Blood 2005; 105(7):2836–2844.
Kirchhoff C, Osterhoff C, Samalecos A. HE6/GPR64 adhesion receptor colocalizes with apical and subapical F-actin scaffold in male excurrent duct epithelia. Reproduction 2008; 136(2):235–245.
Davies B, Baumann C, Kirchhoff C et al. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol 2004; 24(19):8642–8648.
Davies B, Behnen M, Cappallo-Obermann H et al. Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption. Mol Reprod Dev 2007; 74(5):539–553.
Van Itallie CM, Anderson JM. Claudins and epithelial paracellular transport. Annu Rev Physiol 2006; 68:403–429.
Wagenfeld A, Yeung CH, Lehnert W et al. Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. J Androl 2002; 23(6):772–782.
Galligan CL, Baig E, Bykerk V et al. Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity. Genes Immun 2007; 8(6):480–491.
Yamamoto Y, Irie K, Asada M et al. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5) and a novel TEM5-like protein. Oncogene 2004; 23(22):3889–3897.
Seandel M, James D, Shmelkov SV et al. Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature 2007; 449(7160):346–350.
Dym M, He Z, Jiang J et al. Spermatogonial stem cells: unlimited potential. Reprod Fertil Dev 2009; 21(1):15–21.
Formstone CJ, Little PF. The flamingo-related mouse Celsr family (Celsr1–3) genes exhibit distinct patterns of expression during embryonic development. Mech Dev 2001; 109(1):91–94.
Curtin JA, Quint E, Tsipouri V et al. Mutation of Celsrl disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr Biol 2003; 13(13):1129–1133.
Tissir F, Bar I, Jossin Y et al. Protocadherin Celsr3 is crucial in axonal tract development. Nat Neurosci 2005; 8(4):451–457.
Deltagen. MGI Direct Data Submission 2005; MGI:3604450.
Beall SA, Boekelheide K, Johnson KJ. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. J Androl 2005; 26(4):529–538.
Fritz IB. Somatic cell-germ cell relationships inmammalian testes during development and spermatogenesis. Ciba Found Symp 1994; 182:271–274; discussion 274–281.
McMillan DR, Kayes-Wandover KM, Richardson JA et al. Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system. J Biol Chem 2002; 277(1):785–792.
Skradski SL, Clark AM, Jiang H et al. A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron 2001; 31(4):537–544.
McGee J, Goodyear RJ, McMillan DR et al. The very large G-protein-coupled receptor VLGR1: a component of the ankle link complex required for the normal development of auditory hair bundles. J Neurosci 2006; 26(24):6543–6553.
Yagi H, Tokano H, Maeda M et al. Vlgr1 is required for proper stereocilia maturation of cochlear hair cells. Genes Cells 2007; 12(2):235–250.
Weston MD, Luijendijk MW, Humphrey KD et al. Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II. Am J Hum Genet 2004; 74(2):357–366.
Liu M, Parker RM, Darby K et al. GPR56, a novel secretin-like human G-protein-coupled receptor gene. Genomics 1999; 55(3):296–305.
Piao X, Hill RS, Bodell A et al. G protein-coupled receptor-dependent development of human frontal cortex. Science 2004; 303(5666):2033–2036.
Li S, Jin Z, Koirala S et al. GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci 2008; 28(22):5817–5826.
LopezJimenez ND, Sainz E, Cavenagh MM et al. Two novel genes, Gprl13, which encodes a family 2 G-protein-coupled receptor and Trcg1, are selectively expressed in taste receptor cells. Genomics 2005; 85(4):472–482.
Zambrowicz BP, Abuin A, Ramirez-Solis R et al. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci USA 2003; 100(24):14109–14114.
Kiessling AA, Mullen TE, Kiessling RL et al. Detection in Mice and Men of a Novel Class of Leukocyte/Macrophages Essential for Normal Development of Reproductive Tract Tissues. Fertility and sterility 2000; 74(3):S86.
Cohen PE, Nishimura K, Zhu L et al. Macrophages: important accessory cells for reproductive function. J Leukoc Biol 1999; 66(5):765–772.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Landes Bioscience and Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Davies, B., Kirchhoff, C. (2010). Adhesion-GPCRs in the Male Reproductive Tract. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_16
Download citation
DOI: https://doi.org/10.1007/978-1-4419-7913-1_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-7912-4
Online ISBN: 978-1-4419-7913-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)