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Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1

  • Chapter
Adhesion-GPCRs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 706))

Abstract

Brain-specific angiogenesis inhibitor 1 (BAI1) encodes a seven-transmembrane protein that belongs to the adhesion-GPCR family.1–7 Although BAI1 was named for the ability of its extracellular region to inhibit angiogenesis in tumor models, its function in physiological contexts was elusive and remained an orphan receptor until recently.5,6,8–14 BAI1 is now considered a phagocytic receptor that can recognize phosphatidylserine exposed on apoptotic cells. Moreover, BAI1 has been shown to function upstream of the signaling module comprised of ELMO/Dock180/Rac proteins, thereby facilitating the cytoskeletal reorganization necessary to mediate the phagocytic clearance of apoptotic cells.15,16 Here,wereview the phytogeny, structure, associating proteins, as well as the known and proposed functions of BAI1.

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Author information

Authors and Affiliations

  1. Beirne Carter Center for Immunology Research and Department of Microbiology, University of Virginia, Charlottesville, Virginia, USA

    Kodi S. Ravichandran

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  1. Daeho Park
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  2. Kodi S. Ravichandran
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Editors and Affiliations

  1. Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Simon Yona PhD

  2. Institute of Molecular and Cellular Biology, University of Leeds, Leeds, UK

    Martin Stacey DPhil

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Park, D., Ravichandran, K.S. (2010). Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1. In: Yona, S., Stacey, M. (eds) Adhesion-GPCRs. Advances in Experimental Medicine and Biology, vol 706. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7913-1_15

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